Counteracting Congenital Cataract

Arthy Narayanan, B.V. Sai Sinduri, S Pradeep

Abstract

Congenital or hereditary cataract is a condition where the lens of the eye is not completely transparent resulting in cloudy or blocked vision. Many genes have been found to influence the formation of a cataract. The gene that has been focused on in this paper is the CRYAA gene which codes for the crystallin A protein, a major constituent protein of the lens. Mutations and misfoldings of this protein have been seen to be a major cause of congenital cataract. So, we did an analysis of the gene and the protein using computational tools. As a solution to the condition, we computationally devised a vector that carries the correct CRYAA gene. This vector could be used during the pre-natal stage of pregnancy for children who are believed to inherit this condition.

Int. J. Appl. Sci. Biotechnol. Vol 5(2): 216-221

Keywords

CRYAA; Alpha A Crystallin; Congenital cataract

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DOI: http://dx.doi.org/10.3126/ijasbt.v5i2.17620

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