Effect of mitomycin C-aided trabeculectomy on conjunctival goblet cell density

Authors

  • S Mukhopadhyay Regional Institute of Ophthalmology, Kolkata
  • SKD Thakur Regional Institute of Ophthalmology, Kolkata
  • J Dutta Regional Institute of Ophthalmology, Kolkata
  • R Prakash Regional Institute of Ophthalmology, Kolkata
  • C Shaw Regional Institute of Ophthalmology, Kolkata
  • DN Gangopadhyay Department of Dermatology, School of Tropical Medicine and Hygiene, Kolkata
  • H Dutta Regional Institute of Ophthalmology, Kolkata
  • G Bhaduri Regional Institute of Ophthalmology, Kolkata

DOI:

https://doi.org/10.3126/nepjoph.v4i1.5854

Keywords:

trabeculectomy, mitomycin C, goblet cell, conjunctival impression cytology

Abstract

Introduction: Mitomycin C is gaining widespread popularity as an adjunctive with trabeculectomy, as it significantly increases the success rate of the procedure. But it is associated with serious sight-threatening complications.

Materials and methods: Twenty eyes planned for trabeculectomy from the glaucoma clinic were enrolled for the study after obtaining an informed consent. The baseline impression cytology was taken. Ten eyes underwent trabeculectomy with mitomycin C (Group A) and the rest underwent trabeculectomy without any antimetabolites (Group B). Impression cytology samples were taken on months 1, 3, 6, 9 and 12.

Results: In Group A, the difference between goblet cell density preoperatively and 12 month postoperatively was statistically significant (p < 0.0001). In Group B, the difference was not statistically significant. (p = 0.27).

Conclusion: Mitomycin C, though used to augment the success rate of trabeculectomy, has deleterious effect on the conjunctival goblet cell population as is evident from the conjunctival impression cytology.

DOI: http://dx.doi.org/10.3126/nepjoph.v4i1.5854

NEPJOPH 2012; 4(1): 68-72

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How to Cite

Mukhopadhyay, S., Thakur, S., Dutta, J., Prakash, R., Shaw, C., Gangopadhyay, D., Dutta, H., & Bhaduri, G. (2012). Effect of mitomycin C-aided trabeculectomy on conjunctival goblet cell density. Nepalese Journal of Ophthalmology, 4(1), 68–72. https://doi.org/10.3126/nepjoph.v4i1.5854

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Original Articles