Distribution pattern of ABO and Rh blood groups and their allelic frequencies among different ethnic groups in Malaysia

Authors

  • Md. Ruhul Amin Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan
  • Dwi Susanto Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan
  • Laila Naher Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan

DOI:

https://doi.org/10.3126/ajms.v6i4.11257

Keywords:

ABO Blood group, Race, Rh factor, Hardy-Weinberg Law, Malaysia

Abstract

Background: The experiment involved 4 different racial populations such as Malay (M), Chinese (C), Indian Tamil (I) and confounded population termed as Others (O) from 13 states and 1 federal territory in Malaysia.

Methods: A total of 1101 students in Universiti Malaysia Kelantan were surveyed for ABO blood type and Rh factor.

Results: Phenotypic frequencies were 0.24, 0.27, 0.09 and 0.40 in M; 0.26, 0.21, 0.06 and 0.38 in C; 0.27, 0.31, 0.09 and 0.33 in I and 0.11, 0.29, 0.09 and 0.51 in O for A, B, AB and O blood group, respectively. Rh+ve cases were found to be abundant and distributed as 0.92, 0.94, 0.89 and 0.79 among M, C, I and O race, respectively. Allele frequencies of IA, IB and i were estimated at 0.17, 0.20 and 0.63 in M; 0.19, 0.16 and 0.65 in C; 0.20, 0.23 and 0.57 in O, respectively. Insignificant χ2 (0.05, 2 = 5.991) interprets that ABO allele frequencies exist in Hardy-Weinberg equilibrium in all races. However, high magnitude of χ2 in M (5.463) signifies continued admixture in the M genetic population or the population is less stable than C and I. C and I are in more stabilized condition in this regard that might be because of closed breeding within them.

Conclusion: Results of this study might be useful to blood transfusion services in Malaysia apart from human population geneticists.

DOI: http://dx.doi.org/10.3126/ajms.v6i4.11257

Asian Journal of Medical Sciences Vol.6(4) 2015 25-29

 

Downloads

Download data is not yet available.
Abstract
1208
PDF
2386

Author Biography

Md. Ruhul Amin, Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan

Faculty of Agro Based Industry

Associate Professor

Downloads

Published

2014-11-29

How to Cite

Amin, M. R., Susanto, D., & Naher, L. (2014). Distribution pattern of ABO and Rh blood groups and their allelic frequencies among different ethnic groups in Malaysia. Asian Journal of Medical Sciences, 6(4), 25–29. https://doi.org/10.3126/ajms.v6i4.11257

Issue

Section

Original Articles