Changes in serum level of ghrelin, tumor necrosis factor-alpha and interleukin-6 in children with congenital heart disease

Authors

  • Shiv Kumar Yadav Heart Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014,
  • Qi jian YI Heart Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014

DOI:

https://doi.org/10.3126/ajms.v6i5.12129

Keywords:

Ghrelin, Tumor Necrosis Factor-alpha, Interleukin-6, Percutaneous

Abstract

Objective: To investigate the changes in serum levels of ghrelin, tumor necrosis factor-α and interleukin-6 in Children with Congenital Heart Disease (CHD) at pre and post percutaneous management of the lesions.

Material & Methods: We measured the serum levels of ghrelin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assays (ELISA) in 67 patients with CHD and in 20 control subjects; and compared these markers of inflammatory reaction between groups of pre-closure (37 patients) and at the end of 5 minutes (37 patients), 1 month (22 patients) and 3 month (8 patients) post percutaneous management of the lesions.

Results: Our results showed that the patients with CHD had significantly higher serum level of Ghrelin, TNF-α and IL-6 in comparison of the controls but gradually return towards the baseline levels at the end of 3 months post percutaneous management of the lesions.

Conclusion: The inflammatory reaction is activated in pre-closure and self-limited post-closure in children with CHD. Percutaneous management could improve the inflammatory process, which is safe and effective in children with CHD.

DOI: http://dx.doi.org/10.3126/ajms.v6i5.12129

Asian Journal of Medical Sciences Vol.6(5) 2015 12-16

 

 

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Published

2015-05-01

How to Cite

Yadav, S. K., & YI, Q. jian. (2015). Changes in serum level of ghrelin, tumor necrosis factor-alpha and interleukin-6 in children with congenital heart disease. Asian Journal of Medical Sciences, 6(5), 12–16. https://doi.org/10.3126/ajms.v6i5.12129

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Section

Original Articles