Enhanced Plasma H2S Levels Associated With Fasting Blood Glucose In Type-2 Diabetes Mellitus

Authors

  • Pinaki Saha Junior Resident, Department of Biochemistry, NRS Medical College, Kolkata
  • Piyasa Banerjee Research Assistant, Department of Biochemistry, NRS Medical College, Kolkata
  • Prasenjit Pal Junior Resident, Department of Biochemistry, NRS Medical College, Kolkata
  • Lakshmisona Auddya Junior Resident, Department of Biochemistry, NRS Medical College, Kolkata
  • Santanu Sen Assistant Professor, Department of Biochemistry, NRS Medical College, Kolkata
  • Tanmay Jyoti Sau Associate Professor, Department of Medicine, NRS Medical College, Kolkata
  • Arun Kumar Associate Professor, Department of Biochemistry, Manipal College Of Medical Sciences
  • Utpal Kumar Biswas Professor and Head, Department of Biochemistry, NRS Medical College, Kolkata

DOI:

https://doi.org/10.3126/ajms.v6i6.12532

Keywords:

Type 2 Diabetes Mellitus, Plasma H2S levels, Kolkata.

Abstract

Introduction: A number of recent literatures suggest a potential role of H2S and H2S modifying agents in the etiology and management of type-2 diabetes mellitus.

Objective: The current study was aimed to evaluate the plasma levels of H2S in the patients with type 2 Diabetes mellitus and to find out if there is any relationship of H2S concentrations with the fasting blood glucose levels.

Methods: Plasma H2S levels were measured in sixty two recently diagnosed type 2 diabetic patients and compared with similar number of healthy volunteers as controls.

Results: The plasma H2S level in the patients ( 81.17 ± 16.40 micromol/l ) is significantly higher (P< 0.001) than the healthy controls (50.69 ± 8.69 micromol/l) and the H2S levels in plasma have significant positive correlation (r= 0.359, P=0.004) with fasting blood glucose levels.

Conclusion: The present study has elucidated that the patients with type-2 diabetes mellitus are associated with elevated plasma H2S levels which are well correlated with glucose levels. This reveals a potential the role of H2S modulators towards the management of this non-communicable epidemic disorder.

DOI: http://dx.doi.org/10.3126/ajms.v6i6.12532

Asian Journal of Medical Sciences Vol.6(6) 2015 11-15

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Author Biography

Arun Kumar, Associate Professor, Department of Biochemistry, Manipal College Of Medical Sciences

Biochemistry, Associate Professor

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Published

2015-05-13

How to Cite

Saha, P., Banerjee, P., Pal, P., Auddya, L., Sen, S., Sau, T. J., Kumar, A., & Biswas, U. K. (2015). Enhanced Plasma H2S Levels Associated With Fasting Blood Glucose In Type-2 Diabetes Mellitus. Asian Journal of Medical Sciences, 6(6), 11–15. https://doi.org/10.3126/ajms.v6i6.12532

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Original Articles