Combination of bulk laxative along with probiotics and prebiotics in the management of irritable bowel syndrome with constipation: A safe & effective option

Authors

  • Arif Ahmed Faruqui Clinical Pharmacologist, 504 A, Rizvi Mahal, Waterfield road, Bandra (West), Mumbai 400050 Maharashtra http://orcid.org/0000-0002-2491-2800
  • B Jamaiwar M.S, General Surgeon, Nandavan Layout, Nagpur, Maharashtra
  • B Sharma M.D, Medical Officer, Chhindwara-480001

DOI:

https://doi.org/10.3126/ajms.v8i1.12909

Keywords:

Irritable bowel syndrome, probiotics, constipation, prebiotics, ispaghula

Abstract

Background: Irritable bowel syndrome (IBS) is a common and relapsing functional bowel disorder. This disease has a substantial global burden and is associated with significant disability and high costs that adversely affects the health related quality of life of large population worldwide.

Aims and Objective: We studied the efficacy and tolerability of bulk laxative plus probiotic and prebiotic in the treatment of constipation associated IBS (IBS-C) in Indian patients.

Materials and Methods: Eighty patients with symptoms of IBS-C were enrolled in a post-marketing surveillance, multicentre, open label, non-randomized, noncomparative study where EVAQ- P - combination of fiber (psylliun husk/Ispaghula, probiotic and prebiotic) was given BID for 6 weeks. The symptoms were assessed at baseline, and after completion of 2, 4 and 6 weeks of therapy.

Results: Results showed a signifi cant trend (p < 0.0001) of improvement from week 2 for abdominal pain, abdominal fullness, defecation frequency, straining during defecation, constipation and subject global assessment of relief (SGA). Approximately 6% patients showed fl atulence (mild) as a treatment emergent side effect.

Conclusion: Combination of ispaghula along with a blend of probiotics and prebiotic twice daily for 6 weeks is effi cacious, safe, and well-tolerated in IBS-C patients.

Asian Journal of Medical Sciences Vol.8(1) 2017 85-90

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Author Biography

Arif Ahmed Faruqui, Clinical Pharmacologist, 504 A, Rizvi Mahal, Waterfield road, Bandra (West), Mumbai 400050 Maharashtra


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Published

2017-01-03

How to Cite

Faruqui, A. A., Jamaiwar, B., & Sharma, B. (2017). Combination of bulk laxative along with probiotics and prebiotics in the management of irritable bowel syndrome with constipation: A safe & effective option. Asian Journal of Medical Sciences, 8(1), 85–90. https://doi.org/10.3126/ajms.v8i1.12909

Issue

Vol. 8 No. 1 (2017)

Section

Original Articles

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