Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

Authors

  • Enyinnaya A Ogbonnaya Lecturer, Department of Biochemistry, Faculty of Science, University of Port Harcourt, Port Harcourt
  • Patrick O Uadia Professor, Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin, Edo State, Nigeria

DOI:

https://doi.org/10.3126/ajms.v7i5.13615

Keywords:

Telfairia occidentalis, Inorganic composition, Hematological parameters, RDA, Root, Pod, Stem

Abstract

Aims and Objectives: This study is to investigate the inorganic composition and the effect of fourteen (14) -day oral administration of aqueous extracts of root, pod and stem of Telfairia occidentalis in rats.

Materials and Methods: Plant samples were analyzed for K, P, Mg, Ca, S, Mn, Fe, Cu, Zn, Pb, and Cr using atomic absorption spectrophotometry (AAS). Wister rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different animal groups received distilled water and   root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15th day.

Results: The inorganic composition result showed that potassium (K) was the highest in abundance in all the samples (root, pod, and stem), compared to the other mineral elements. The root contained high levels of potassium and manganese; the stem had magnesium, manganese and iron while the pod contained high amount of potassium, manganese and iron. Hematological assay results showed reduction in the values of white blood cell (WBC) count for higher doses of root extract and all doses (except for 1500mg/kg bw) of pod extract. Platelet count (PLT) was significantly high for root extract at 750mg/kg bw. The stem extract showed a consistent decrease in the red blood cell (RBC) count for all dose administered.

Conclusion: Telfairia occidentalis root, pod, and stem may be a good source of inorganic elements. The extracts have varying effects on hematological parameters which may be dosage- and duration- dependent.

Asian Journal of Medical Sciences Vol.7(5) 2016 75-80

Downloads

Download data is not yet available.
Abstract
764
PDF
620

Downloads

Published

2016-08-31

How to Cite

Ogbonnaya, E. A., & Uadia, P. O. (2016). Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats. Asian Journal of Medical Sciences, 7(5), 75–80. https://doi.org/10.3126/ajms.v7i5.13615

Issue

Vol. 7 No. 5 (2016)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).