Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

Authors

  • R Raman Thulasi Assistant Professor, Department of Pathology Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu
  • D Manimaran Professor, Department of Pathology Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu
  • G Hemanathan Resident, Department of Pathology Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu
  • Tameem Afroz Senior Consultant, Department Of Pathology, Aware Global, Hospitals, Hyderabad, Telangana
  • Radha Sagar Senior Consultant and HOD, Department of Pathology Aware Global Hospitals, Hyderabad, Telangana

DOI:

https://doi.org/10.3126/ajms.v7i4.14033

Keywords:

Anemia, Leucopenia, Thrombocytopenia, HIV, CD4 Count, ART

Abstract

Background: HIV is pandemic and remains as a public health concern for many decades. This infection though associated with many opportunistic infections and neoplasms, it is further complicated with marked hematological abnormalities. The aim of this study is to determine the magnitude & severity of hematological abnormalities in HIV infected individuals and also to analyze these abnormalities in correlation with the CD4 counts. We also compared these hematological abnormalities in patients on ART and those not on ART.

Materials and Methods: The study was conducted for a period of one year, on 120 HIV positive cases including both patients on ART & not on ART. Controls with similar age and sex distribution was set up. The blood samples were collected and processed in an automated cell counter. The parameters were tabulated and analyzed with respect to CD4 count & ART status.

Results: Among the total of 120 HIV cases, 77% had anemia, 21% had leucopenia and 5% had thrombocytopenia. The magnitude and severity of anemia, leucopenia, thrombocytopenia and other parameters was found to be more in patients not on ART, when compared to patients on ART. Similarly, the magnitude and severity of most of hematological abnormalities were inversely proportional to the CD4 count in non-ART cases but not with cases on ART.

Conclusion: The basic hematological parameters can be used as a prospective screening test to assess the severity and progression of HIV infection when CD4 count is not available. These parameters can also be used to assess the response to anti-retroviral treatment. Therefore, these basic hematological investigations readily available at all medical centers are of great use while treating HIV infected patients.

Asian Journal of Medical Sciences Vol.7(4) 2016 14-18

 

Downloads

Download data is not yet available.
Abstract
1165
PDF
2065

Downloads

Published

2016-07-04

How to Cite

Thulasi, R. R., Manimaran, D., Hemanathan, G., Afroz, T., & Sagar, R. (2016). Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status. Asian Journal of Medical Sciences, 7(4), 14–18. https://doi.org/10.3126/ajms.v7i4.14033

Issue

Vol. 7 No. 4 (2016)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).