Serum Reproductive hormone levels in male symptomatic HIV/AIDS patients on Antiretroviral therapy negative to Malaria parasite in Nnewi, Anambra State, Nigeria

Keywords: HIV, AIDS, Malaria negative, Male subjects, Reproductive hormones, ART

Abstract

Background: AIDS is an endemic disease that causes death among young adults worldwide especially in Nigeria.

Aims and Objectives: This study investigated the serum reproductive hormone levels in symptomatic HIV/AIDS male subjects on ART who are negative to malaria parasite in Nnewi, Anambra State, Nigeria.

Materials and Methods: A total of 274 adult male participants aged between 18 and 60 years were randomly recruited, and grouped into: symptomatic HIV (stage 11) infected male participants on ART (A: n=69), Symptomatic HIV subjects not on ART (B: n= 69), Asymptomatic HIV positive subjects (C: n= 68) and HIV seronegative subjects (D: n= 68). Serum was used to assay for PSA, LH, FSH, Estrogen, Testosterone, Progesterone and Prolactin levels. Analysis of variance and student t-test were used for data analyses.

Results: The serum levels of PSA, FSH, Estrogen, Testosterone, Progesterone and Prolactin were significantly different amongst the groups at p<0.05 respectively. There were significantly higher levels of PSA, Estrogen, Progesterone but lower levels of Testosterone and Prolactin in subjects on ART compared with control at p<0.05 respectively. There were significantly higher levels of PSA, FSH, Estrogen,Progesterone but lower levels of Testosterone in subjects not on ART compared with control at p<0.05 respectively.

Conclusion: The reduction on serum levels of Testosterone and higher levels in FSH, PSA, Estrogen, and Progesterone may reveal presence of hypogonadism, primary testicular failure, prostate abnormalities such as cancer and hyperprogesteronaemia, in symptomatic HIV positives.

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Author Biographies

Priscilla Ifeoma Ezeugwunne, Nnamdi Azikiwe University, Nnewi, Nigeria

Lecturer, Department of Human Biochemistry, Faculty of Basic Medical Sciences

Chukwuemeka Emmanuel Ogbodo, Nnamdi Azikiwe University, Nnewi, Nigeria

Senior Medical Laboratory Scientist, Department of Medical Laboratory Science, Faculty of Health Sciences

Adamma Rosemary Analike, Nnamdi Azikiwe University, Nnewi, Nigeria

Chief Medical Laboratory Scientist, Department of Chemical Pathology, Faculty of Medicine

Nwando Chikaodili Obi-Ezeani, Chukwuemeka Odumegwu Ojukwu University, Awka, Nigeria

Senior Medical Laboratory Scientist, Department of Chemical Pathology

Joy Ifeoma Onuora, Nnamdi Azikiwe University, Nnewi, Nigeria

Chief Medical Laboratory Scientist, Department of Chemical Pathology, Faculty of Medicine

Nwabunwanne Victor Oguaka, Nnamdi Azikiwe University, Nnewi, Nigeria

Lecturer, Department of Human Biochemistry, Faculty of Basic Medical Sciences

Kalu Ubou Amah, Nnamdi Azikiwe University, Nnewi, Nigeria

Senior lecturer, Department of Chemical Pathology, Faculty of Medicine

Chukwuemeka Michael Ugwu, Nnamdi Azikiwe University, Nnewi, Nigeria

Senior lecturer, Department of Chemical Pathology, Faculty of Medicine

Chinedum Charles Onyenekwe, Nnamdi Azikiwe University, Nnewi, Nigeria

Professor, Department of Chemical Pathology, Faculty of Medicine

Eberendu Joseph Ahaneku, Nnamdi Azikiwe University, Nnewi, Nigeria

Professor, Department of Chemical Pathology, Faculty of Medicine

Published
2019-05-01
How to Cite
Ezeugwunne, P., Ogbodo, C., Analike, A., Obi-Ezeani, N., Onuora, J., Oguaka, N., Amah, K., Ugwu, C., Onyenekwe, C., & Ahaneku, E. (2019). Serum Reproductive hormone levels in male symptomatic HIV/AIDS patients on Antiretroviral therapy negative to Malaria parasite in Nnewi, Anambra State, Nigeria. Asian Journal of Medical Sciences, 10(3), 44-49. https://doi.org/10.3126/ajms.v10i3.22505
Section
Articles