Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study

  • Sandhya Iyer Thyrocare Technologies Limited, India
  • Rajkumar Kushawaha Thyrocare Technologies Limited, India
  • Prachi Sinkar Thyrocare Technologies Limited, India
  • Sivakumar Selvaraj Thyrocare Technologies Limited, India
  • Amruta Velumani Thyrocare Technologies Limited, India
Keywords: Lipoprotein Phospholipase A2, Cardiac Risk, Cholesterol, India, LDL, Triglycerides

Abstract

Background: Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditional lipid markers and Lp-PLA2 in a pan-India cohort.

Materials and Methods: The study cohort included a total of 10347 pan-Indians including 5945 males and 4402 females respectively. The serum lipid parameters estimated include triglycerides, LDL- and HDL-cholesterol as well as total cholesterol by the technology of photometry.

Results: The frequency of high Lp-PLA2 detected in our study was 6.4% and the frequency between males at 9.3% and females at 2.5% was detected to be significant at p<0.0001. Linear regression analysis detected significant positive association of high Lp-PLA2 with LDL-cholesterol and total cholesterol at p<0.05, while the trend with HDL-cholesterol was also significant. However, Lp-PLA2 as an independent marker was not detected to be significant in relation to the lipid indices studied.

Conclusion: Though Lp-PLA2 has been associated with risk factor for acute coronary crisis, its clinical value remains controversial. Our report though detected significant association of Lp-PLA2 with various lipid parameters, independent value remains questionable.

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Author Biographies

Sandhya Iyer, Thyrocare Technologies Limited, India

Biochemistry Division, Thyrocare Technologies Limited, Turbhe,
Navi Mumbai - 400703, India

Rajkumar Kushawaha, Thyrocare Technologies Limited, India

Biochemistry Division, Thyrocare Technologies Limited, Turbhe,
Navi Mumbai - 400703, India

Prachi Sinkar, Thyrocare Technologies Limited, India

Biochemistry Division, Thyrocare Technologies Limited, Turbhe,
Navi Mumbai - 400703, India

Sivakumar Selvaraj, Thyrocare Technologies Limited, India

Biochemistry Division, Thyrocare Technologies Limited, Turbhe,
Navi Mumbai - 400703, India

Amruta Velumani, Thyrocare Technologies Limited, India

Biochemistry Division, Thyrocare Technologies Limited, Turbhe,
Navi Mumbai - 400703, India

Published
2019-05-01
How to Cite
Iyer, S., Kushawaha, R., Sinkar, P., Selvaraj, S., & Velumani, A. (2019). Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study. Asian Journal of Medical Sciences, 10(3), 1-6. https://doi.org/10.3126/ajms.v10i3.22791
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Articles