AST to platelet ratio index for predicting the in hospital mortality in chronic liver disease patients in tertiary care hospital

Keywords: AST to platelet ration index, Model of end stage liver disease, Area under curve, Alanine transaminase, Hepatitis C virus

Abstract

Background: Liver cirrhosis is the end result of chronic liver injury. Cirrhosis of liver may progressively deteriorate from a well-compensated state to decompensated conditions.

Aims and Objective: Our study aims at evaluating the AST to Platelet Ratio Index (APRI) for predicting the in-hospital mortality and also comparing APRI, MELD and albumin for predicting in hospital mortality in chronic liver disease.

Materials and Methods: Data of Patients with Chronic liver disease were retrospectively reviewed. MELD and APRI scores were calculated for the patients and results from ROC curves were analysed.

Results: In our study conducted on 299 patients, the age distribution was between 18-64 years with mean age of patients being 46.47+/-10.9 years, sex ratio Male: Female: 266:37 with mortality rate of 17.7%. The area under curves of ROC of APRI, MELD and Albumin are 0.63, 0.76 and 0.55.

Conclusion: APRI is an independent predictor of mortality. The prognostic performance of all 3 was comparable but MELD has better prognostic significance than APRI score.

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Author Biographies

BS Nagaraja, Bangalore Medical College and Research Institute, KR road, Bangalore, Karnataka, India

Professor and Head, Department of Medicine

R Madhumati, Bangalore Medical College and Research Institute, KR road, Bangalore, Karnataka, India

Professor, Department of Medicine

HR Avinash, Bangalore Medical College and Research Institute, KR road, Bangalore, Karnataka, India

Post graduate, Department of Medicine

KJ Umesh, Bangalore Medical College and Research Institute, KR road, Bangalore, Karnataka, India

Post graduate, Department of Medicine

Published
2019-06-21
How to Cite
Nagaraja, B., Madhumati, R., Avinash, H., & Umesh, K. (2019). AST to platelet ratio index for predicting the in hospital mortality in chronic liver disease patients in tertiary care hospital. Asian Journal of Medical Sciences, 10(4), 44-48. https://doi.org/10.3126/ajms.v10i4.23170
Section
Articles