Comparative analysis on association of fasting and postprandial dyslipidemia with risk of atherosclerosis in early rheumatoid arthritis

  • Puja Kumari Jha University College of Medical Sciences and Guru Teg Bahadur Hospital (University of Delhi), Delhi-110095, India https://orcid.org/0000-0002-4662-9897
  • Rafat Sultana Ahmed University College of Medical Sciences and Guru Teg Bahadur Hospital (University of Delhi), Delhi-110095, India https://orcid.org/0000-0003-3421-0236
  • Rachna Agarawal Institute of human behavior and allied sciences (IHBAS), Delhi-110095, India
Keywords: Early rheumatoid arthritis, Dyslipidemia, Post prandial, Inflammation, Atherosclerosis

Abstract

Background: Rheumatoid arthritis (RA) patients have higher cardiovascular risk due todyslipidemia, inflammation etc. The serum lipid levels obtained after 12 hour fasting will not truly reflect atherosclerotic risk associated as non fasting state predominates in routine life.

Aim and Objectives: We investigated the frequency of dyslipidemia in early RA cases and healthy controls in both fasting and postprandial state and analyzed the impact of postprandial lipid profile over fasting lipid levels in prediction of atherosclerotic risk.

Materials and Methods: This case-control study was conducted at UCMS and GTB Hospital, Delhi. 127 RA cases diagnosed according to revised ACR, 2010 with age and sex matched 127 controls were recruited. Lipid profile parameters were analyzed by commercial kits on auto analyzer. RF, anti-CCP, TNF-α and CRP were measured by ELISA. For statistical analysis unpaired t test and Pearson’s correlation was used.

Result: The mean disease duration was 7± 2.16 months. There were significant increased levels of TC, LDL-C, and TAG with reduced serum HDL-C in RA cases. Atherogenic ratio of TC/HDL-C and LDL-C/HDL-C were significantly high in RA. Postprandial lipid analysis revealed significant difference for TAG and HDL-C in RA cases. TAG had a significantly positive correlation with TNF-α (r=0.234) which improved in postprandial state(r=0.559). Significantly negative correlation of HDL-C with ESR (r=-0.221) also improved (r=-0.421) postprandially.

Conclusions: Atherogenic dyslipidemia was a significant finding in patients of early RA. Dyslipidemia screening can be recommended in postprandial state.

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Author Biographies

Puja Kumari Jha, University College of Medical Sciences and Guru Teg Bahadur Hospital (University of Delhi), Delhi-110095, India

Senior Resident, Department of Biochemistry

Rafat Sultana Ahmed, University College of Medical Sciences and Guru Teg Bahadur Hospital (University of Delhi), Delhi-110095, India

Director Professor, Department of Biochemistry

Rachna Agarawal, Institute of human behavior and allied sciences (IHBAS), Delhi-110095, India

Associate Professor, Department of Neurochemistry

Published
2019-05-01
How to Cite
Jha, P., Ahmed, R., & Agarawal, R. (2019). Comparative analysis on association of fasting and postprandial dyslipidemia with risk of atherosclerosis in early rheumatoid arthritis. Asian Journal of Medical Sciences, 10(3), 7-12. https://doi.org/10.3126/ajms.v10i3.23283
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Articles