Oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria

Authors

  • Mohammed Haruna Yeldu Associate Professor, School of Medical Laboratory Sciences, Usmanu Danfodiyo University Sokoto, Nigeria.
  • Yakubu Ibrahim Principal Medical Laboratory scientist, Department of Medical Laboratory Services, Gombe State Specialist Hospital, Gombe-Nigeria.
  • Shehu Abubakar Akuyam Professor, Department of Medical Laboratory Science, Ahmadu Bello University, Zaria.
  • Isah Muhammad Danasabe Consultant Physician and Senior Lecturer, Department of Internal Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
  • Buhari Shehu Lecturer I, School of Medical Laboratory Sciences, Usmanu Danfodiyo University Sokoto, Nigeria.
  • Mohammed Danjuma Chief Medical Laboratory Scientist, Federal Medical Centre, Birnin Kebbi, Nigeria.
  • Miftahu Bello Senior Medical Laboratory Scientist, State Specialist Hospital, Sokoto, Nigeria.
  • Usman Yahaya Lecturer II, Department of Medical Laboratory Science, Ahmadu Bello University Zaria.

DOI:

https://doi.org/10.3126/ajms.v10i6.25593

Keywords:

Pulmonary tuberculosis, oxidative stress, Gombe-Nigeria

Abstract

Background: Oxidative stress may play an important role in the pathogenesis of pulmonary tuberculosis (PTB). To our knowledge there is paucity of data on the status of oxidative stress biomarkers among PTB patients in Gombe, North-eastern Nigeria. Our study was designed to evaluate the oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria.

Aims and Objectives: To determine the serum levels of oxidative stress biomarkers among patients with pulmonary tuberculosis in Gombe metropolis, North-eastern Nigeria and to assess the correlation between the oxidative stress biomarkers in pulmonary tuberculosis patients.

Materials and Methods: A cross sectional comparative study was conducted in a tertiary health care facility with 40 pulmonary tuberculosis (PTB) patients on anti-TB drugs treatment (ATT), 40 newly diagnosed PTB patients not yet on anti-TB drugs treatment (ATT-naïve) and 40 age- and sex-marched apparently healthy subjects (controls). Serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), nitric oxide (NO) and oxidative stress index (OSI) determined using standard techniques. Data was analysed using INSTAT® (Graph Pad Software Inc., La Jolla, CA, USA).

Results: Serum levels of TOS, OSI, MDA and NO were significantly (p ˂ 0.001) increased in PTB patients (ATT and ATT-naïve) when compared with healthy individuals. Serum TAS and body mass index (BMI) were significantly (p ˂ 0.001) decreased in PTB patients when compared with healthy individuals. Serum TOS significantly correlated with serum OSI, MDA and NO in ATT-naïve PTB patients.

Conclusion: This study observed an increased oxidative stress biomarkers and decreased total antioxidant status in newly diagnosed pulmonary tuberculosis patients and those on treatment. Our findings suggest that antioxidants supplementation and improved nutrition in the management of pulmonary tuberculosis patients may go a long way in preventing the oxidative onslaught and further complications in PTB patients.

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Published

2019-10-30

How to Cite

Yeldu, M. H., Ibrahim, Y., Akuyam, S. A., Danasabe, I. M., Shehu, B., Danjuma, M., Bello, M., & Yahaya, U. (2019). Oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria. Asian Journal of Medical Sciences, 10(6), 57–62. https://doi.org/10.3126/ajms.v10i6.25593

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Section

Original Articles