The distribution of hepatitis C virus genotypes in patients with hepatocellular carcinoma

Authors

  • Ayfer Bakır Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul, Turkey http://orcid.org/0000-0002-9006-5267
  • Nuran Karabulut Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul, Turkey http://orcid.org/0000-0003-3550-2599
  • Sema Alaçam Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul, Turkey http://orcid.org/0000-0001-7957-2906
  • Barış Bakır Istanbul University, Istanbul Faculty of Medicine, Department of Radiology, Istanbul, Turkey http://orcid.org/0000-0002-6587-9787
  • Ali Ağaçfidan Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul, Turkey

DOI:

https://doi.org/10.3126/ajms.v10i6.25720

Keywords:

HCV, HCV genotype, Hepatocellular carcinoma

Abstract

Background: Hepatic cirrhosis develops within 20-30 years in approximately 20% of individuals chronically infected with hepatitis C virus (HCV).

Aims and Objective: This study aimed to determine the distribution of HCV genotypes in patients with HCV-associated HCC in our region and thus to contribute to the epidemiology of HCV.

Materials and Methods: HCC patients referred to the virology laboratory for HCV genotype identification between January 2013 and April 2018 were included in this study. Genotyping of HCV was performed by a commercial reverse hybridization line probe-based assay.

Results: Seventeen patients who were diagnosed with HCC and whose HCV genotypes were analyzed were included in this study. Genotype 1 was detected in all 17 patients with HCC. When evaluating subtypes of genotype 1, genotype 1b was detected in 16 (94%) of the patients. The HCV subtyping in one patient (6%) could not be performed.

Conclusion: As a result, genotype 1b, one of the major risk factors for HCC, was detected in 94% of the patients included in this study. This study, consistent with the literature, shows a high association between the development of HCC and genotype 1b in patients with chronic HCV.

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Published

2019-10-30

How to Cite

Bakır, A., Karabulut, N., Alaçam, S., Bakır, B., & Ağaçfidan, A. (2019). The distribution of hepatitis C virus genotypes in patients with hepatocellular carcinoma. Asian Journal of Medical Sciences, 10(6), 28–32. https://doi.org/10.3126/ajms.v10i6.25720

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Section

Original Articles