Lipid-lowering and anti-lipase properties of powder fractions of Dichrostachys glomerata fruits

Authors

  • Ngatchic Metsagang Therese Josiane Department of Food Science and Nutrition, National School of Agro-industrial Science, Ngaoundere, P.O. Box 455, University of Ngaoundere, Cameroon https://orcid.org/0000-0002-5385-5518
  • Douanla Nodem Forestine Nikaise Department of Food Science and Nutrition, National School of Agro-industrial Science, Ngaoundere, P.O. Box 455, University of Ngaoundere, Cameroon
  • Ndjantou Elie Baudelaire Department of Food Science and Nutrition, National School of Agro-industrial Science, Ngaoundere, P.O. Box 455, University of Ngaoundere, Cameroon https://orcid.org/0000-0002-3699-3652
  • Njintang Yanou Nicolas Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, Ngaoundere, Cameroon https://orcid.org/0000-0002-8949-7150

DOI:

https://doi.org/10.3126/ajms.v11i5.29229

Keywords:

Dichrostachys glomerata, Fractions powder, Antihyperlipidemia, Hypolipidemia, Anti-lipase

Abstract

Background: Fruits of Dichrostachys glomerata have in the last ten years benefited from special attention as a lipid-lowering plant. Recent studies show that biological activities of some plants depend on granulometry of their powder particles.

Aims and Objective: The purpose of this study was to assess antihyperlipidemic, hypolipidemic, and anti-lipase properties of powder fractions of the fruits of Dichrostachys glomerata.

Materials and Methods: The groups of rats on which the antihyperlipidemic test was done were fed with High Fat Diet and supplemented with powder fractions: ≥180μm, 212–180μm, 315–212μm, ≥315 μm and unsieved powder of Dichrostachys glomerata fruits at dose of 250 mg/kg for four weeks. For the hypolipidemic test, the diet was changed to normal diet and the powder fraction: 212 – 180μm, was given to rats for four weeks. Lipase inhibitory activity was determined using olive oil as substrate.

Results: The antihyperlipidemic test showed that powder fractions reduced levels of total cholesterol, LDL-Cholesterol and triglycerides, groups taken powder fractions 212 –180µm and <180µm, presented the lowest values. HDL-Cholesterol levels increased, significant increases were observed in groups fed with powder fractions 315–212µm, 212–180µm, <180µm and unsieved powder. Concerning hypolipidemic test, powder fraction 212–180 µm decreased levels of total cholesterol, LDL-Cholesterol and triglycerides. 86.43% of the activity of pancreatic lipase was reduced to a concentration of 25mg/ml with an IC50 of 5mg/ml.

Conclusion: Antihyperlipidemic properties of Dichrostachys glomerata fruits depended on powder fractions. Fraction 180-212μm exhibits hypolipidemic effects. The inhibition of pancreatic lipase is one of the mechanisms which could explain lipid- lowering properties of Dichrostachys glomerata fruits.

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Published

2020-09-01

How to Cite

Josiane, N. M. T., Nikaise, D. . N. F., Baudelaire, N. E., & Nicolas, N. Y. (2020). Lipid-lowering and anti-lipase properties of powder fractions of Dichrostachys glomerata fruits. Asian Journal of Medical Sciences, 11(5), 69–76. https://doi.org/10.3126/ajms.v11i5.29229

Issue

Vol. 11 No. 5 (2020)

Section

Original Articles

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