The prevalence of thyroid dysfunction in patients with connective tissue disorders

Authors

DOI:

https://doi.org/10.3126/ajms.v12i7.34998

Keywords:

Connective tissue disorder, Thyroid dysfunction, Hypothyroidism, Subclinical hypothyroidism, Hyperthyroidism, Systemic lupus erythematous, Scleroderma, Sjogren’s syndrome, Rheumatoid arthritis, Vasculitis

Abstract

Background: Abnormalities in thyroid function have been reported in patients with connective tissue disorders. In India many patients suffer from thyroid dysfunction and rheumatological disorders. There is a lack of awareness of thyroid dysfunction in patients suffering from connective tissue disorders. Also, studies regarding the same are lacking in India.

Aims and Objective: The current study was undertaken to estimate the Prevalence of Thyroid dysfunction in connective tissue disorders.

Materials and Methods: It’s a duration based, prospective cross-sectional study including 100 patients. Patients presenting with connective tissue disorders were evaluated for thyroid function clinically and were subjected to serum TSH, Free T3, Free T4 and Anti-thyroid antibodies. The association was analyzed using frequency analysis, percentage analysis, and Chi-Square test.

Results: Of the 100 patients in this study, predilection of connective tissue disorders was seen among females. The overall prevalence of thyroid dysfunction in patients with connective tissue disorder was 41%. 22% of the 100 patients had Anti-TPO antibodies suggestive of autoimmune thyroiditis. Our study showed 42.1% of the patients with rheumatoid arthritis, 45.5% of the patients with Systemic Lupus Erythematosus, 50% of the patients with Sjogren’s syndrome, 27.3% of the patients with Systemic sclerosis, and 42.9% of the patients with mixed connective tissue disorder had thyroid dysfunction.

Conclusion: Our study demonstrates the increased prevalence of thyroid dysfunction among patients with connective tissue disorders and shows a female preponderance, in the age group of 45-65 years. Hence, early screening and intervention will prevent significant morbidity and improve the quality of patients’ life.

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Author Biography

Jayashankar Chinnappa Anjanappa, Professor and Head, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, India

Professor and HOD Department of Internal Medicine

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Published

2021-07-01

How to Cite

Jones, D., Anjanappa, J. C., Hiremath, S., Siddaraju, A., Hanumantha Reddy, C. K., Sampoornam, S. A., Manpreeth, E., & Prashanthi, S. V. S. R. (2021). The prevalence of thyroid dysfunction in patients with connective tissue disorders. Asian Journal of Medical Sciences, 12(7), 33–36. https://doi.org/10.3126/ajms.v12i7.34998

Issue

Vol. 12 No. 7 (2021)

Section

Original Articles

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