Impact of Lymphocyte Apoptosis in Diabetes mellitus

Authors

  • Awadhesh K Arya Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Deepa Pokharia Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Hemant Kumar Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Manish Mishra Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Kamlakar Tripathi Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi

DOI:

https://doi.org/10.3126/ajms.v2i1.3516

Keywords:

Lymphocyte, Infection, Programmed cell death, Autoantigens, Gene

Abstract

Diabetes mellitus is a metabolic disorder. It is the most common cause of blindness, kidney failure, and amputations in adults and a leading cause of heart disease and stroke. These patients are more prone to infection which shows that there is suppressed cell mediated immunity during diabetes progression. Lymphocytes play a crucial role in  maintenance of cellular & humoral immunity both and its development requires cellular selection to remove potentially auto reactive cells via apoptosis. Apoptosis of lymphocyte clones play a pivotal role in purging the body of dangerous lymphocytes to maintain the development and regulation of the immune system. Indeed, inefficient elimination of lymphocytes can contribute in the pathogenesis of autoimmune diseases like insulin dependent diabetes mellitus. Several clinical and experimental studies have revealed that uncontrolled diabetes leads to lymphocyte death which enhances susceptibility towards infections and creates a permissive environment for bacterial growth. The aim of this article is to review the findings that the high incidence of infection in poorly  controlled diabetic states may be positively correlated with an increased proportion of apoptotic lymphocytes.

Keywords: Lymphocyte; Infection; Programmed cell death; Autoantigens; Immunity

 

DOI: 10.3126/ajms.v2i1.3516

Asian Journal of Medical Sciences 2 (2011) 1-6

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Published

2011-05-14

How to Cite

Arya, A. K., Pokharia, D., Kumar, H., Mishra, M., & Tripathi, K. (2011). Impact of Lymphocyte Apoptosis in Diabetes mellitus. Asian Journal of Medical Sciences, 2(1), 1–6. https://doi.org/10.3126/ajms.v2i1.3516

Issue

Vol. 2 No. 1 (2011)

Section

Original Articles

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