Variable presentations of systemic lupus erythematosus based on presence or absence of antidouble stranded DNA antibodies: A case series

Authors

  • Somnath Maitra Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0001-7906-3570
  • Swapan Sarkar Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0003-0007-052X
  • Biswaroop Mukherjee Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0002-0112-8941
  • Suprotim Ghosh Post Graduate Trainee, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0002-2632-0980

DOI:

https://doi.org/10.3126/ajms.v13i1.40369

Keywords:

Anti-double stranded DNA, Kidney, Systemic lupus erythematosus

Abstract

Systemic lupus erythematosus (SLE) presents with diverse clinical features causing diagnostic challenges. Apart from the clinical features, autoantibodies are important for diagnosis along with certain laboratory parameters. Diagnosis is made with the European League against Rheumatism/American College of Rheumatology 2019 Criteria. The case series presented here signifies the correlation between anti ds DNA positivity and its association with poor prognosis and renal disease, whereas antidouble stranded DNA (anti-dsDNA) negativity may lead to lack of renal involvement and may be associated with polyserositis. The importance lies in the fact that these patients with anti-dsDNA negativity should be followed up for assessing conversion to positivity of anti-dsDNA, thus altering the prognosis and leading to renal involvement. Moreover, anti-SSA positive SLE patients must be followed up for possible development of sicca symptoms.

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Published

2022-01-01

How to Cite

Maitra, S., Sarkar, S., Mukherjee, B., & Ghosh, S. (2022). Variable presentations of systemic lupus erythematosus based on presence or absence of antidouble stranded DNA antibodies: A case series. Asian Journal of Medical Sciences, 13(1), 175–179. https://doi.org/10.3126/ajms.v13i1.40369

Issue

Vol. 13 No. 1 (2022)

Section

Case Series

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Copyright (c) 2021 Asian Journal of Medical Sciences

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