An assessment of the frequency of blood transfusion before and after starting hydroxyurea therapy in children of sickle cell anemia

Authors

DOI:

https://doi.org/10.3126/ajms.v13i2.41506

Keywords:

sickle cell anemia, hydroxyurea therapy in sickle cell patients, blood transfusion in sickle cell anemia patients

Abstract

Background: Hydroxyurea therapy is a known effective and safe therapy for the treatmentof sickle cell anemia (SCA). Although it is used worldwide in our Madhya Pradesh basedsetup, it is underutilized due to economic reasons and unaware practitioners about itsuse.

Aims and Objectives: The Objective of the study is to assess the frequency ofblood transfusion year before and after starting hydroxyurea therapy in children of SCA.

Materials and Methods: An ambispective observational study was performed at MGM Medical College Indore over a period of 1 year 8 months. One hundred and ninety patients were enrolled after taking a complete history, then started on Hydroxyurea and followed up every 2 months till 1 year. On follow-up, frequency of blood transfusion was noted along with routine investigations and for any side effects.

Results: Of 190 total recruited patients, 84 were studied at the end because of loss to follow-up due to various reasons. Significant decrease in the need for blood transfusion was observed within 1 year of starting Hydroxyurea (P<0.05).

Conclusion: The use of hydroxyurea in our native population at our setup can decrease the need for frequent blood transfusion in sickle cell patients.

Downloads

Download data is not yet available.
Abstract
156
PDF
221

Downloads

Published

2022-02-01

How to Cite

Gupta, S., Chaudhary, P. ., Chauhan, A., & Malpani, . P. (2022). An assessment of the frequency of blood transfusion before and after starting hydroxyurea therapy in children of sickle cell anemia. Asian Journal of Medical Sciences, 13(2), 81–85. https://doi.org/10.3126/ajms.v13i2.41506

Issue

Vol. 13 No. 2 (2022)

Section

Original Articles

License

Copyright (c) 2022 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).