Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

Authors

  • Rashmi Raghavendra Assistant Professor, Department of Anaesthesiology and Critical Care, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India https://orcid.org/0000-0003-3937-0028
  • Surekha Kumar Postgraduate Resident, Department of Anaesthesiology and Critical Care, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India https://orcid.org/0000-0001-5037-2222
  • Sowmya Madihalli Janardhan Iyengar Professor, Department of Anaesthesiology and Critical Care, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India https://orcid.org/0000-0002-0962-3234

DOI:

https://doi.org/10.3126/ajms.v13i10.45314

Keywords:

Intravenous; Magnesium sulfate; Intubation; Percutaneous nephrolithotomy; Sore throat

Abstract

Background: Multiple drugs in different routes have been studied for the treatment of post-operative sore throat (POST). We are studying effect of magnesium sulfate on POST in two different routes.

Aims and Objectives: This study aims to compare the efficacy of nebulization versus intravenous (IV) magnesium sulfate in reducing incidence of POST and hoarseness of voice.

Materials and Methods: This prospective randomized double-blind study was done on 150 patients undergoing unilateral percutaneous nephrolithotomy (PCNL) surgeries under general anesthesia. Patients were randomly allocated into Group N (n=75) and Group I (n=75). Group N received 10 mg/kg MgSO4 in 5 mL of normal saline as nebulization 20 min before induction and 100 mL normal saline IV over 20 min post-induction. Group I received 5 mL of normal saline as nebulization pre-induction and 10 mg/kg MgSO4 in 100 mL saline IV over 20 min post-induction. Postoperatively, visual analog scale (VAS) score was used for the assessment of sore throat at rest and dynamic VAS (DyVAS) for pain during swallowing at the 0, 1st, 6th, 12th, and 24th h. Post-operative hoarseness graded on 4-point score was also assessed.

Results: Incidence of POST in Group N was 29.17% compared to 52.86% in Group I at 0 h which was lower and statistically significant and results were alike at the 1st and 6th h. The VAS at rest and DyVAS were lower and statistically significant in Group N compared to Group I at the 0, 1st, and 6th h.

Conclusion: Incidence of POST was significantly less with nebulized route of magnesium sulfate compared to IV route of magnesium sulfate.

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Published

2022-10-01

How to Cite

Rashmi Raghavendra, Surekha Kumar, & Sowmya Madihalli Janardhan Iyengar. (2022). Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial. Asian Journal of Medical Sciences, 13(10), 29–34. https://doi.org/10.3126/ajms.v13i10.45314

Issue

Vol. 13 No. 10 (2022)

Section

Original Articles

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