Efficacy of d-dimer level as a prognostic indicator in COVID-19 infection
DOI:
https://doi.org/10.3126/ajms.v15i4.60975Keywords:
Coronavirus disease 2019; Coagulopathy; D-DimerAbstract
Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, was first reported in China in 2019 and later declared a pandemic. Coagulation abnormalities play the pivotal role in causing most of the symptoms related to COVId-19 infection. As the pathophysiology of COVID-19 is now being understood, it is found that these coagulation abnormalities, especially thrombosis are very well related to the severity of the disease. D-dimer is a potential biomarker for various thrombotic diseases. This study aims to determine the efficacy of D-dimer, Fibrinogen, Prothrombin time (PT), and activated partial thromboplastin time (aPTT) to determine the severity of COVID-19 infection.
Aims and Objectives: The objectives of the study are as follows: (1). To determine the efficacy of D-dimer in assessing the severity of the disease in COVID-19 infection. (2). To determine the role of PT, aPTT, and Fibrinogen levels in assessing the severity of COVID-19 Infection.
Materials and Methods: The study was conducted among 160 reverse transcription polymerase chain reaction confirmed COVID-19 patients admitted in Government Medical College, Kottayam. The sociodemographic profile and presenting complaints were obtained using a structured format. Blood samples were collected on the day of admission, the 5th day, and 10th day. Samples are tested for levels of D-dimer, Fibrinogen, PT, and aPTT. Based on the clinical outcome, patients were categorized into two groups: Mild group and severe group.
Results: The difference between the median D-dimer at admission in the severe group (1339 ng/mL) and the mild group (390 ng/mL) was statistically significant. Area under the receiver operating characteristic (ROC) for D-dimer was 0.774 and cut-off value was found to be 569 μg/mL with a sensitivity of 83.3% and a specificity of 61.2%. The ROC curve analysis, area under the curve of PT also can be used for diagnosis with 76.3% with 76.3% sensitivity and 61.2% of specificity.
Conclusion: Coagulopathy is an important complication of COVID-19 patients and is related to severity as well as prognosis of disease. D-dimer and PT can be used as reliable and convenient parameter for assessing coagulopathy and severity in COVID-19 infected patients.
Downloads
37
33
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
