@article{Iyer_Kushawaha_Sinkar_Selvaraj_Velumani_2019, title={Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study}, volume={10}, url={https://www.nepjol.info/index.php/AJMS/article/view/22791}, DOI={10.3126/ajms.v10i3.22791}, abstractNote={<p><strong>Background: </strong>Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditional lipid markers and Lp-PLA2 in a pan-India cohort.</p> <p><strong>Materials and Methods: </strong>The study cohort included a total of 10347 pan-Indians including 5945 males and 4402 females respectively. The serum lipid parameters estimated include triglycerides, LDL- and HDL-cholesterol as well as total cholesterol by the technology of photometry.</p> <p><strong>Results: </strong>The frequency of high Lp-PLA2 detected in our study was 6.4% and the frequency between males at 9.3% and females at 2.5% was detected to be significant at p<0.0001. Linear regression analysis detected significant positive association of high Lp-PLA2 with LDL-cholesterol and total cholesterol at p<0.05, while the trend with HDL-cholesterol was also significant. However, Lp-PLA2 as an independent marker was not detected to be significant in relation to the lipid indices studied.</p> <p><strong>Conclusion: </strong>Though Lp-PLA2 has been associated with risk factor for acute coronary crisis, its clinical value remains controversial. Our report though detected significant association of Lp-PLA2 with various lipid parameters, independent value remains questionable.</p>}, number={3}, journal={Asian Journal of Medical Sciences}, author={Iyer, Sandhya and Kushawaha, Rajkumar and Sinkar, Prachi and Selvaraj, Sivakumar and Velumani, Amruta}, year={2019}, month={May}, pages={1–6} }