TY - JOUR AU - Yusuf, Sadiq AU - Agunu, Abdulkareem AU - Katung, Nna Venessa AU - Umana, Uduak PY - 2010/05/07 Y2 - 2024/03/29 TI - Ethanolic Leaf Extract of Psidium Guajava L. [Myrtaceae] Protects the Stomach against Ischemia-Reperfusion Induced Gastric Mucosal Injury JF - Asian Journal of Medical Sciences JA - Asian J Med Sci VL - 1 IS - 1 SE - Original Articles DO - 10.3126/ajms.v1i1.2452 UR - https://www.nepjol.info/index.php/AJMS/article/view/2452 SP - 1-3 AB - <p><strong>Objective:</strong> Decoction of the root, bark or leaves of Psidium guajava universally known guava has a long history of dietary and medicinal uses in Africa. This study was designed to investigate the gastric secretory and protective properties of leaf extract of guava on ischemia-reperfusion (I-R) induced gastric mucosal injury in rats.</p><p><strong>Methods: </strong>Male Wistar rats (n = 40) were divided in eight groups. Group 1 served as control group, group 2 animals were subjected to I-R without treatment, groups 3, 4, 5 and 7 were pretreated with 25, 50, 100 mg/kg of the extract orally 10 mg/kg indomethacin intraperitoneally [i.p.] 30 min before I-R respectively. Group 6 animals were pretreated with indomethacin [10mg/kg, i.p.] without I-R while group 8 animals were administered with 100mg/kg guava extract 30&nbsp;&nbsp; minutes before administration of indomethacin [10mg/kg, i. p.] and subjected to I-R. Extent of mucosal damage was assessed by calculating the ulcer index while adherent mucus was determined by the Alcian Blue method.</p><p><strong>Results:</strong> The results obtained indicated that oral pretreatment of rats with extract of guava leaves significantly reduced and reversed I-R induced mucosal injury (P &lt; 0.001), reduced gastric acid and adherent mucus on the gastric mucosa (P &lt; 0.05) respectively. Indomethacin aggravated the mucosal injury induced by I-R which was reversed by 100 mg/kg extract of guava.</p><p><strong>Conclusion:</strong> In conclusion, the stimulation of mucus secretion by guava extract may be responsible for its gastro-protective properties against I-R induced mucosal injury.</p><p><strong>Keywords:</strong> guava extract; gastric mucosa; ischemia-reperfusion; indomethacin; Psidium guajava</p><p>DOI: 10.3126/ajms.v1i1.2452</p><p><em>Asian Journal of Medical Sciences</em> Vol.1(1) 2010 p.1-3</p> ER -