TY - JOUR AU - Gupta, Richa K. AU - Thakuri, Ganesh M. S. AU - Bajracharya, Gan B AU - Jha, Ram Narayan PY - 2021/06/09 Y2 - 2024/03/29 TI - Synthesis of antioxidative anthraquinones as potential anticancer agents JF - BIBECHANA JA - BIBECHANA VL - 18 IS - 2 SE - Research Articles DO - 10.3126/bibechana.v18i2.31234 UR - https://www.nepjol.info/index.php/BIBECHANA/article/view/31234 SP - 143-153 AB - <p>Antioxidant and antibacterial activities of natural anthraquinones namely chrysophanol (<strong>1</strong>) and emodin (<strong>2</strong>), and synthesized anthraquinones <em>viz.</em> 2-methylanthraquinone (<strong>3</strong>), anthraquinone (<strong>4</strong>), 2-bromoanthraquinone (<strong>5</strong>), rubiadin (<strong>6</strong>), chrysophanol diacetate (<strong>7</strong>), rubiadin diacetate (<strong>8</strong>) and 1,8-dimethoxy-3-methylanthraquinone (<strong>9</strong>) were investigated. Anthraquinones <strong>9</strong>, <strong>3</strong>, <strong>6</strong>, <strong>5</strong> and <strong>2</strong> exhibited a high DPPH• radical scavenging capacity (IC<sub>50</sub> = &lt;500 μg/mL) showing their therapeutic potentiality for the treatment of cancers. These anthraquinones <strong>1</strong>-<strong>9</strong> have also displayed a weak to moderate antibacterial activity against <em>Bacillus subtilis</em>. Chrysophanol diacetate (<strong>7</strong>) including emodin (<strong>2</strong>) have been appeared as the valuable antibacterials.</p><p>BIBECHANA 18 (2) (2021) 143-153</p> ER -