Effects of Titanium Dioxide Nanoparticles Toxicity on the Kidney of Male Rats

  • Fatemeh Mohammadi Fartkhooni Department of Biology, PayamNor University of Isfahan, Isfahan
  • Ali Noori Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan
  • Abdolrasool Mohammadi A highly qualified teacher in Isfahan province
Keywords: Nano-TiO2, Kidney tissue, Renal factors, Toxicity

Abstract

Nanoparticles have many characteristics that make them suitable for biological and medical applications. These special features cause some adverse effects. Despite the widespread use of titanium dioxide nanoparticles, few studies were conducted on the toxicity of these nanoparticles in biological systems. In this study, the effects of intraperitoneal injections of TiO2 nanoparticles (30,50,70 mg/kg ) were investigated on kidney function and histology. The creatinine levels did not change but the amount of urea and uric acid showed the significant changes in comparison with control group. But, by passing the time, the uric acid changes back to normal. In kidney tissue, the changes such as deposition of hyaline-like materials, the swelling, dilatation of Bowman's capsule and degenerations were seen. It seems by passing time, The temporary disorders have been removed and the renal function has returned toward normal. However, further investigations are needed to measure the oxidative stress.

International Journal of Life Sciences 10 (1) : 2016; 65-69

Downloads

Download data is not yet available.
Abstract
2742
PDF
2844
Published
2016-02-10
How to Cite
Fartkhooni, F., Noori, A., & Mohammadi, A. (2016). Effects of Titanium Dioxide Nanoparticles Toxicity on the Kidney of Male Rats. International Journal of Life Sciences, 10(1), 65-69. https://doi.org/10.3126/ijls.v10i1.14513
Section
Research Articles