Association of Preoperative mid-stream urine culture, Renal pelvic urine culture and Renal stone culture in the detection of Systemic inflammatory response syndrome/urosepsis post Percutaneous Nephrolithotomy

Keywords: Percutaneous Nephrolithotomy, Sepsis, Urine culture

Abstract

Introduction: Urosepsis post Percutaneous Nephrolithotomy (PCNL) is a dreaded complication with high mortality rate. Objective: To find the association of preoperative midstream urine culture (PMUC), renal pelvic urine culture (RPUC) and renal stone culture (RSC) in the post-operative development of Systemic Inflammatory Response Syndrome (SIRS) and urosepsis.

Methods: It was a prospective cross-sectional observational study. The study included all symptomatic patients meeting the inclusion criteria who underwent Percutaneous Nephrolithotomy from 18th August, 2019 to 28th March, 2020. PMUC, RPUC and RSC were done and analyzed accordingly.

Results: A total of 140 (73 males, 67 females) patients underwent PCNL. PMUC was positive in 15% (21/140) as compared to RPUC and RSC which were 7.9 % (11/140) and 4.3% (6/140) of total cases. None of the patients had simultaneous culture positivity in all the three types of specimens. Only two (1.42%) patients had simultaneous positivity in pelvic urine culture and stone culture. The organisms obtained in pelvic urine culture and stone culture were same i.e. Klebsiella and Escherichia coli respectively. Only two (1.42%) patients developed SIRS post PCNL, where in both the cases stone culture were positive but PMUC and RPUC were negative. Urosepsis was found in none of the patients. In the Fischer Exact test PMUC and RPUC were not statistically significant in the detection of SIRS post PCNL. Whereas only RSC showed statistical significance in the detection of SIRS.

Conclusion: Stone culture has high prediction for SIRS and it might be considered for patients undergoing PCNL in order to prevent stone related infective complications.  

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Author Biographies

Neeraj Thapa, Lumbini Medical College

Assistant Professor, Department of Surgery

Suman Baral, Lumbini Medical College

Department of Surgery

Nabina Maharjan, Lumbini Medical College

Department of Microbiology

Raj Kumar Chettri, Lumbini Medical College

Department of Surgery

Suminma Acharya, Lumbini Medical College

Department of Radiology

Kamal Karki, Lumbini Medical College

Department of Surgery

Ranjit Mahato, Lumbini Medical College

Department of Surgery

Published
2020-06-18
How to Cite
Thapa, N., Baral, S., Maharjan, N., Chettri, R., Acharya, S., Karki, K., & Mahato, R. (2020). Association of Preoperative mid-stream urine culture, Renal pelvic urine culture and Renal stone culture in the detection of Systemic inflammatory response syndrome/urosepsis post Percutaneous Nephrolithotomy. Journal of Gandaki Medical College-Nepal, 13(1), 14-18. https://doi.org/10.3126/jgmcn.v13i1.29378
Section
Original Articles