Comparison of left ventricular global longitudinal strain by speckle tracking echocardiography in patients with and without diabetes mellitus asymptomatic for coronary artery disease at a tertiary hospital in Nepal

Authors

DOI:

https://doi.org/10.3126/jkmc.v11i4.53665

Keywords:

Coronary artery disease, Diabetes mellitus, Global longitudinal strain, Silent myocardial ischaemia, Speckle tracking echocardiography

Abstract

Background: Diabetes mellitus is a major risk factor for cardiovascular events. A significant proportion of diabetics are asymptomatic for ischaemic heart disease either because of the early stage of ischaemia or silent myocardial ischaemia. Global longitudinal strain (GLS) of the left ventricle measured by speckle tracking echocardiography (STE) is a novel method of detecting left ventricular dysfunction due to myocardial ischaemia.
Objectives: This study aimed to compare the GLS of type-2 diabetes mellitus (T2DM) and non-diabetic patients who were asymptomatic for coronary artery disease (CAD).
Methods: An analytical cross-sectional study was conducted among 52 diabetic and 49 non-diabetic individuals asymptomatic for CAD presenting to a tertiary hospital, between 2022 September to 2022 October. The STE was performed to measure left ventricular GLS of the participants. Their blood and urine samples were sent for measuring glycosylated haemoglobin (HbA1c), total cholesterol, and microalbuminuria. Data were entered and analysed using SPSS v23.
Results: Twenty-five (48.1%) diabetics had left ventricular dysfunction (GLS ?18) compared to two (4.1%) non-diabetics. GLS was significantly lower among the diabetic patients, and exhibited significant inverse correlation with the duration of diabetes, age, HbA1c, and microalbuminuria (p <0.001). In multiple linear regression model for GLS, only the duration of diabetes (B = -0.27, p <0.001) and the age of patients (B = -0.057, p = 0.004) retained statistical significance, after adjusting for other covariates.
Conclusion: Left ventricular GLS has a significant negative correlation with the duration of diabetes and age of the patients.

Downloads

Download data is not yet available.
Abstract
41
PDF
33

Downloads

Published

2022-12-31

How to Cite

Shrestha, S. K., Khadka, T., & Shrestha, A. P. (2022). Comparison of left ventricular global longitudinal strain by speckle tracking echocardiography in patients with and without diabetes mellitus asymptomatic for coronary artery disease at a tertiary hospital in Nepal. Journal of Kathmandu Medical College, 11(4), 240–246. https://doi.org/10.3126/jkmc.v11i4.53665

Issue

Section

Original Research Articles

Most read articles by the same author(s)