@article{Giri_Sharma_2022, title={Biogenic Synthesis of Silver Nanoparticles Using Terminalia chebula Retz. Leaf Extract and Evaluation of Biological Activities }, volume={43}, url={https://www.nepjol.info/index.php/JNCS/article/view/46957}, DOI={10.3126/jncs.v43i1.46957}, abstractNote={<p>Nanoparticles have been used in various fields of science and technology ranging from material science to biotechnology. The formation of nanoparticles has been confirmed through UV-visible spectroscopy (at 420 nm) by the change of color representing surface plasmon resonance. The synthesis of silver nanoparticles by a biogenic method is a novel approach due to its cost-effective, eco-friendly, and large-scale production possibilities. In the present study, silver nanoparticles (TC-AgNPs) were successfully synthesized using <em>Terminalia chebula </em>Retz. (<em>T. chebula</em>) leaf extract. Characterization of green synthesized silver nanoparticles was performed using UV-visible <em>spectroscopy</em>, Fourier transforms infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The formation of nanoparticles has been confirmed through UV-visible spectroscopy (at 420 nm) by the change of color representing surface plasmon resonance. The crystalline face-centred cubic property of the biosynthesized silver nanoparticles was established using XRD analysis. The XRD data gave the average particle size of 6.1 nm.  The functional groups such as -OH, C=O, =NH were found responsible for reducing silver ions and helping to stabilize nanoparticles which were analyzed using FTIR spectroscopy. As the silver nanoparticles possess diverse applications, TC-AgNPs were investigated for antioxidant, antibacterial, and cytotoxic activity. The results showed TC-AgNPs showed potential antioxidant (IC<sub>50</sub>=312.8 ± 2.28 µg/mL) and antibacterial activities against four pathogenic bacteria like <em>Staphylococcus aureus</em>, <em>Acinetobacter baumannii</em>, <em>Salmonella typhi</em>, and <em>Escherichia coli</em>. Also, the silver nanoparticles exhibited moderate cytotoxicity (LC<sub>50</sub>= 477.53 ± 0.684 µg/mL) against brine shrimps nauplii in a dose-dependent manner. </p>}, number={1}, journal={Journal of Nepal Chemical Society}, author={Giri, Ramesh and Sharma, Khaga}, year={2022}, month={Aug.}, pages={54–68} }