TY - JOUR AU - Aryal, Sangam AU - Shrestha, Sunita AU - Devkota, Anil AU - Bhandari, Netra Lal AU - Jha, Ram Narayan PY - 2020/07/29 Y2 - 2024/03/29 TI - FTIR, GC-MS Analysis and Bioactivity Studies of Withania somnifera L. of Nepalese Origin JF - Journal of Nepal Chemical Society JA - J. Nepal Chem. Soc. VL - 41 IS - 1 SE - Articles DO - 10.3126/jncs.v41i1.30374 UR - https://www.nepjol.info/index.php/JNCS/article/view/30374 SP - 36-45 AB - <p>Present study evaluates the bio-constituents and bioactivity of extract from roots and stems of <em>Withania somnifera</em> (<em>Aswagandha</em>) of Nepalese origin. The phytochemical screening of methanol and n-hexane extracts revealed the presence of alkaloids, flavonoids, phenols, tannins, quinone, carbohydrates, resins, xanthoprotein<em> etc</em>. The FTIR analysis helped to confirm the functional groups of various medicinally important compounds. The DPPH percentage radical scavenging activity of methanolic and hexane extracts are found to be 3.587 ± 0.004, and 4.484 ± 0.003 µg/mL respectively. The antioxidant activity of the plant goes after the number of total phenolics and flavonoids present on it. GC-MS analysis revealed the presence of more than 14 different compounds in the extract. Moreover, the methanol and hexane extract of plant showed 25.8% and 12.9% α-glucosidase inhibitory activity respectively. The results of the study revealed the medicinal values and pharmacological significance of the plant.</p> ER -