TY - JOUR AU - Tella, Adedibu C. AU - Obaleya, Joshua A. PY - 2010/06/18 Y2 - 2024/03/29 TI - Synthesis of Some 3d Metal Complexes of Quinine and their Toxicological Studies JF - Journal of Nepal Chemical Society JA - J. Nepal Chem. Soc. VL - 25 IS - 0 SE - Articles DO - 10.3126/jncs.v25i0.3280 UR - https://www.nepjol.info/index.php/JNCS/article/view/3280 SP - 19-28 AB - <p>Four metal complexes of antimalarials cinchona alkaloids; [Co(Quin)Cl<sub>3</sub>]<strong>-1</strong>,<br />[Fe(Quin)Cl<sub>2</sub>H<sub>2</sub>O]SO3H<sub>2</sub>O<strong>-2</strong>, [Cu(Quin)ClSO<sub>4</sub>]&infin;<strong>-3</strong> and [Cd(Quin)ClSO<sub>4</sub>]&infin;<strong>-4</strong> have been<br />synthesized and characterized by elemental analysis, conductivity, magnetic moment, IR,<br />UV-Vis and mass spectroscopic techniques. The tetrahedral geometry is assigned for all the<br />four complexes and the quinine ligand is protonated at quinuclidine N atom with the<br />coordination of the metal at quinoline N atom for all the complexes. Complexes <strong>1</strong> and <strong>2</strong><br />have zwitterionic structures while complexes <strong>3</strong> and <strong>4</strong> are polymeric in nature with zig-zag<br />extended chains (MCl- O -SO<sub>2<sup>-</sup></sub> O -MCl- O &ndash;SO<sub>2<sup>---</sup></sub>).<br />Stability constant of the complexes were evaluated for the metal salts. The value of the<br />stability constant (&beta;) was found to be log 10.48, 9.92, 7.98 and 7.81 for Cu(II), Fe(III),<br />Co(II) and Cd(II), respectively and the order of &beta; was found to be<br />Cu(II)&gt;Fe(III)&gt;Co(II)&gt;Cd(II). The stability constant data revealed that concomitantly<br />administration of quinine with preparation containing these metals may reduce their<br />efficacy. Toxicological study was carried out by investigating the effect of administration of<br />the complexes on alkaline phosphatase activity of kidney, liver and serum of Albino rats. All<br />the examined four metal complexes were found to be non-toxic.</p><p><strong>Keywords:</strong> Quinine, stability constant, FTIR, MS, phosphates activity.</p><p>DOI:&nbsp; 10.3126/jncs.v25i0.3280<br /><em><br />Journal of Nepal Chemical Society</em> Volume 25, 2010 pp 19-28</p> ER -