Comparison of Propofol-Ketamine Combination with Propofol-Butorphanol Combination for Total Intravenous Anaesthesia on Short Surgical Procedures

  • Nabin Kumar Regmi Department of Anaesthesia Nepalgunj Medical College Teaching Hospital Kohalpur, Banke
  • Santosh Khatri Department of Anaesthesia Nepalgunj Medical College Teaching Hospital Kohalpur, Banke
  • Prashanta Kumar Datta Department of Anaesthesia Nepalgunj Medical College Teaching Hospital Kohalpur, Banke
Keywords: Hemodynamic stability, Propofol-butorphanol, Propofol-ketamine, Respiratory stability, Sedation, Total Intravenous anaesthesia

Abstract

Objectives: The objective of this study was to compare propofol-ketamine combination with propofol-butorphanol combination for short surgical procedures in terms of hemodynamic and respiratory stability, postoperative sedation, postoperative nausea and vomiting and effect of abolishing pain on injection with propofol.

Methods: This was a randomized double blinded study conducted in 60 patients belonging to ASA I &II, aged between 16 - 60 years. Patients were divided into two groups: Group-B: Propofol- Butorphanol combination (n=30) and Group-K: Propofol-Ketamine combination (n=30). The baseline values for the heart rate, mean arterial pressure and SPO recorded and every 5 minutes after induction of anesthesia.

Results: In Butorphanol group MAP at 5, 10, 2 15, 20, 25 and 30 minutes after induction was significantly lesser but heart rate at 10, 15, 20, 25 and30 minutes after induction was significantly greater than in the Ketamine group with the p value of < 0.05. From 20-30 minutes post induction, SPO in Butorphanol 2 group was significantly less than in the Ketamine group with the p value of < 0.05. Pain after injection of propofol was significantly greater in Ketamine group with the p value of 0.008. There was no statistically significant sedation and post operative nausea and vomiting among the groups.

Conclusion: Propofol-Ketamine combination provided better hemodynamic and respiratory stability than Propofol-Butorpanol combination however pain on injection with propofol was greater in Propofol-ketamine combination.

JNGMC Vol. 12 No. 2 December 2014, Page: 34-39

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Published
2016-02-04
How to Cite
Regmi, N., Khatri, S., & Datta, P. (2016). Comparison of Propofol-Ketamine Combination with Propofol-Butorphanol Combination for Total Intravenous Anaesthesia on Short Surgical Procedures. Journal of Nepalgunj Medical College, 12(2), 34-39. https://doi.org/10.3126/jngmc.v12i2.14474
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Original Articles