Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates

  • Piush Kanodia Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal
  • Sudesh Shrestha Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal
  • Santosh Gautam Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal
  • Sachin Chawla Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal
Keywords: Perinatal asphyxia, Creatine kinase muscle-brain fraction, CK-MB, Lactate dehydrogenase (LDH), Hypoxic ischemic encephalopathy (HIE)

Abstract

Background: The enzymes CK-MB & LDH are used as potential predictors of timing and grade of HIE in newborns with perinatal asphyxia.

Objectives: To differentiate HIE neonates from non-HIE ones on the basis of significant rise of LDH & CK-MB.

Methodology: Prospective cross-sectional analytical study. Among 164 newborns, 82 comprising the cases and 82 neonates comprising the controls met the inclusion and exclusion criteria. The umbilical cord blood samples for CK-MB and LDH was drawn and sent for analysis. A serum CK-MB value >92.6 U/L and LDH value >580 U/L was taken as the cut-off level. Descriptive statistical analyses were done to find the significance between two groups. ROC Curve analysis was performed to find the diagnostic performance of CK-MB and LDH.

Results: Out of total 164 neonates studied, 18.3% had moderate HIE & 11%had severe HIE while 56.1%had No HIE. Seventy-two newborns were found to have LDH levels >580 U/L out of which 71 were in case group and 1 was in control group. Among the 164 neonates studied, 7.9% from case group were found to have CK-MB levels >92.6 U/L. Both the results of LDH & CK-MB levels were very significant with P value <0.001. Area under ROC (Receiving operating Characteristic) value of LDH when compared to CK-MB is (0.978 vs. 0.731).

Conclusion: Estimation of CK-MB and LDH enzymes can help to distinguish asphyxiated from non-asphyxiated term neonates when correlating with their history and clinical features.

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Author Biographies

Piush Kanodia, Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal

Associate Professor, Department of Paediatrics

Sudesh Shrestha, Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal

Department of Paediatrics

Santosh Gautam, Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal

Department of Paediatrics

Sachin Chawla, Nepalgunj Medical College & Teaching Hospital Nepalgunj, Banke, Nepal

Department of Paediatrics

Published
2020-05-03
How to Cite
Kanodia, P., Shrestha, S., Gautam, S., & Chawla, S. (2020). Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates. Journal of Nepalgunj Medical College, 17(2), 2-6. https://doi.org/10.3126/jngmc.v17i2.28749
Section
Original Articles