TY - JOUR AU - Regmi, Nabin Kumar AU - Khatri, Santosh AU - Datta, Prashanta Kumar PY - 2016/02/04 Y2 - 2024/03/29 TI - Comparison of Propofol-Ketamine Combination with Propofol-Butorphanol Combination for Total Intravenous Anaesthesia on Short Surgical Procedures JF - Journal of Nepalgunj Medical College JA - J. Nepalgunj Med. College VL - 12 IS - 2 SE - Original Articles DO - 10.3126/jngmc.v12i2.14474 UR - https://www.nepjol.info/index.php/JNGMC/article/view/14474 SP - 34-39 AB - <p><strong>Objectives</strong>: The objective of this study was to compare propofol-ketamine combination with propofol-butorphanol combination for short surgical procedures in terms of hemodynamic and respiratory stability, postoperative sedation, postoperative nausea and vomiting and effect of abolishing pain on injection with propofol.</p><p><strong>Methods</strong>: This was a randomized double blinded study conducted in 60 patients belonging to ASA I &amp;II, aged between 16 - 60 years. Patients were divided into two groups: Group-B: Propofol- Butorphanol combination (n=30) and Group-K: Propofol-Ketamine combination (n=30). The baseline values for the heart rate, mean arterial pressure and SPO recorded and every 5 minutes after induction of anesthesia.</p><p><strong>Results</strong>: In Butorphanol group MAP at 5, 10, 2 15, 20, 25 and 30 minutes after induction was significantly lesser but heart rate at 10, 15, 20, 25 and30 minutes after induction was significantly greater than in the Ketamine group with the p value of &lt; 0.05. From 20-30 minutes post induction, SPO in Butorphanol 2 group was significantly less than in the Ketamine group with the p value of &lt; 0.05. Pain after injection of propofol was significantly greater in Ketamine group with the p value of 0.008. There was no statistically significant sedation and post operative nausea and vomiting among the groups.</p><p><strong>Conclusion</strong>: Propofol-Ketamine combination provided better hemodynamic and respiratory stability than Propofol-Butorpanol combination however pain on injection with propofol was greater in Propofol-ketamine combination.</p><p><strong>JNGMC</strong> Vol. 12 No. 2 December 2014, Page: 34-39</p> ER -