@article{Sharma_Yenamandra_Kalita_Dash_Singh_2019, title={Comparison of Oral Trichlophos and Intranasal Midazolam for Sedation in Minimally Invasive Paediatric Procedures (RAMT Study)}, volume={38}, url={https://www.nepjol.info/index.php/JNPS/article/view/19139}, DOI={10.3126/jnps.v38i2.19139}, abstractNote={<p><strong>Introduction: </strong>Uncooperative child does not allow completion of procedures, denying valuable data required for clinicians.</p> <p><strong>Material and Methods: </strong>An open labelled parallel group prospective randomized control study was conducted at zonal hospital Jorhat. We evaluated 200 children randomized into two groups using computer based randomization. Participants aged 3 months to 5 years (<em>n</em>=200) were randomized to receive 50 mg/kg Triclofos sodium orally or intranasal spray of midazolam 0.2 mg/kg.</p> <p><strong>Results: </strong>Adequate sedation (Ramsay reactivity score of 3 and 4) was obtained in 86% children in midazolam group as compared to 80% in triclofos group with p value of 0.138. Mean duration for onset of sedation was 20 min ± 5.4 min in Trichlophos group and 12 min ± 4.5 min with Intranasal Midazolam which was statistically significant with <em>p</em>-value of <0.001. The mean duration of post procedural sedation was found to be 24.00 ± 9.21 min in midazolam group and 49.00 ± 16.99 min in triclofos group (<em>p</em>=<0.001) which was statistically significant. No significant difference was seen for side effects frequency between the two drugs (15% in Triclofos, 10% in Midazolam group; <em>p</em>=0.285).</p> <p><strong>Conclusion: </strong>We conclude that intranasal midazolam is more effective than oral trichlophos with a comparable safety profile.</p> <p>CTRI Trial Number: /2017/08/009448.  </p>}, number={2}, journal={Journal of Nepal Paediatric Society}, author={Sharma, Manoj and Yenamandra, Kamal K. and Kalita, Jitu and Dash, Shaswat and Singh, Daljit}, year={2019}, month={Jan.}, pages={80–83} }