TY - JOUR AU - Dash, Dillip Kumar AU - Dash, Mrutunjaya AU - Mohanty, M.D. AU - Acharya, Naresh PY - 2017/04/16 Y2 - 2024/03/28 TI - Efficacy of Probiotic Saccharomyces boulardii as an Adjuvant Therapy in Acute Childhood Diarrhoea JF - Journal of Nepal Paediatric Society JA - J. Nepal Paedtr. Soc. VL - 36 IS - 3 SE - Original Articles DO - 10.3126/jnps.v36i3.15539 UR - https://www.nepjol.info/index.php/JNPS/article/view/15539 SP - 250-255 AB - <p><strong>Introduction</strong>: Administration of <em>S. boulardii </em>in addition to rehydration therapy in diarrhea found to be beneficial in many aspects owing to a variety of causes and importantly it is was not associated with any adverse effects.</p><p><strong>Material and Methods</strong>: We conducted a prospective study of children suffering from acute diarrhoea, at a private tertiary care hospital. Children were divided into 2 groups randomly as per odd(Group 1 ) and even (Group 2) bed allotted in indoor at the time of admission: Group 1 included children on oral rehydration therapy (ORT) + Zinc + <em>Saccharomyces boulardii </em>(Probiotic 5 billion CFU twice daily) and Group 2 comprised of children on ORT+ Zinc. Our objective was to systematically review data on the effect of <em>S. boulardii </em>on acute childhood diarrhoea.</p><p><strong>Results: </strong>Out of a total of 126 children less than 2 years, 2-6 years and 6-14 years were 72 (57.14%), 42(33.33%) and 12(09.52%) respectively. The duration of diarrhoea in Group 1 was 26.31 hours and Group 2 was 47.81 hours (<em>p</em>&lt;0.01). The frequency of diarrhoea showed improvement within 24 and 72 hours in Group 1 and Group 2 respectively (<em>p</em>&lt;0.01).Similarly, the mean duration of hospital stay was 2.68 days in Group 1 and 4.8 days in Group 2.The treatment cost was INR 850 and INR 1650 while social cost was INR 1250 and 2600 in Group 1 and 2 respectively.</p><p><strong>Conclusion:</strong>This study shows that <em>S. boulardii </em>reduced the duration, frequency and hospital stay of diarrhoea thereby reducing the treatment and social costs.</p><p>J Nepal Paediatr Soc 2016;36(3):250-255</p> ER -