TY - JOUR AU - Jiao, Fuyong AU - Guo, Xiangyang AU - Lin, Jin AU - Cui, Wei AU - Li, Huirong PY - 2010/07/13 Y2 - 2024/03/28 TI - A Randomized Trial of Ligustrazini Hydrochlorioi in the Treatment of Viral Encephalitis in Children JF - Journal of Nepal Paediatric Society JA - J. Nepal Paedtr. Soc. VL - 30 IS - 2 SE - Novel Therapy DO - 10.3126/jnps.v30i2.3451 UR - https://www.nepjol.info/index.php/JNPS/article/view/3451 SP - 119-122 AB - <strong>Introduction:</strong> Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viral<br />encephalitis. In animal studies it has shown to inhibit the synthesis and activity of Thromboxane (TXA2)<br />and abate the imbalance between Thromboxane (TXA2) and Prostacyclin (PGI2). As a result, cerebral<br />edema, ischemia and hypoxia could be improved. The aim of this study is to evaluate its effect in the<br />treatment of viral encephalitis in children. <strong>Methodology:</strong> Ninety-nine patients with viral encephalitis<br />were randomly divided into two groups. Ligustrazini Hydrochlorioi (LH) consisting of 51 cases (males<br />30, females 21; age 5 years and nine month &plusmn;8 years and 2month) was given LH 4mg/kg per day in 100-<br />300mls of 10% glucose and infused intravenously over a three to four hour period, for 7 days as a course<br />of treatment. A control groups of 48 cases (males 31, females 17; age 5 years and three month &plusmn;4 years<br />and three month) received the conventional treatment of Vitamin C(2.0-3.0g), Coenzyme A(100u) and<br />Adenosine Triphosphate (ATP) (40mg) in 100-300 mls of 10% glucose infused intravenously daily for 7<br />days. <strong>Results:</strong> The total response rate in the LH group and the control group were 94.12% and 68.75%<br />respectively (u=3.271 p&lt;0.05). The average time to improvement was 4.29&plusmn;1.41 days and 7.31&plusmn;2.66<br />days respectively. No adverse effect was observed in both groups. <strong>Conclusion:</strong> We conclude that LH is<br />an effective, safe and well tolerated treatment for children encephalitis.<br /><br /><strong>Key words:</strong> Cerebral Oedema; Encephalitis; Ligustrazini Hydrochlorioi<br /><br />DOI: 10.3126/jnps.v30i2.3451<br /><br /><em>J. Nepal Paediatr. Soc.</em> May-August, 2010 Vol 30(2) 119-122 ER -