@article{Yadav_Wang_Hua_Lu_2020, title={Membrane expression and significance of TRAIL death receptors DR4 and DR5 in Pancreatic cancer}, volume={7}, url={https://www.nepjol.info/index.php/JPAHS/article/view/33827}, DOI={10.3126/jpahs.v7i3.33827}, abstractNote={<p><strong>Introduction</strong>: Tumor necrosis factor related-apoptosis-inducing ligand (TRAIL) is a powerful and selective activator of apoptosis in many cancer cells. We aim to investigate the expression and significance of TRAIL death receptor DR4 and DR5 in pancreatic cancer (PC) tissues.</p> <p><strong>Method: </strong>Twenty-eight histologically verified samples of PC tissue were collected between 2018 and 2019. TRAIL death receptor expression profiles were determined by immunohistochemistry.</p> <p><strong>Result:</strong> Death receptor DR4 and DR5 were expressed in the PC tissue and the adjacent non-cancerous pancreatic tissues, the expression of DR4 and DR5 in the PC tissue was significantly higher than that of the adjacent non-cancerous pancreatic tissues (p<0.05). Additionally, in both the tissue group, the expression of DR4 was significantly stronger than the DR5 (p<0.05). To assess the relationship between DR4 and DR5 expression, differentiation, and tumor staging of PC, the result reveals that the expression of DR4 and DR5 was significantly higher in stage I tumors than the stage II, III, IV tumors (p<0.05). In contrast, the expression of DR4 and DR5 was decreased with a decrease in the degree of differentiation of tumors. However, the difference was not statistically significant.</p> <p><strong>Conclusion:</strong> The membrane expression of TRAIL death receptor DR4 and DR5 is greater in PC than in the adjacent non-cancerous pancreatic tissues. Furthermore, increased membrane expression of TRAIL death receptor DR4 and DR5 in stage I PC and well-differentiated PC may predict the prognosis and feasibility of using TRAIL gene therapy as a treatment option for early PC.</p>}, number={3}, journal={Journal of Patan Academy of Health Sciences}, author={Yadav, Dipesh Kumar and Wang, Ze Sheng and Hua, Yong Fei and Lu, Cai De}, year={2020}, month={Dec.}, pages={54–61} }