TY - JOUR AU - Pradhan, SV PY - 2012/09/25 Y2 - 2024/03/29 TI - Autoimmune Hepatitis: A Review with emphasis on its histomorphology JF - Journal of Pathology of Nepal JA - J Pathol Nep VL - 2 IS - 4 SE - Review Articles DO - 10.3126/jpn.v2i4.6887 UR - https://www.nepjol.info/index.php/JPN/article/view/6887 SP - 317-323 AB - <p><span style="font-family: Calibri;">Autoimmune hepatitis is a chronic inflammatory disorder characterized by periportal inflammation, hypergammaglobulinemia with elevated autoantibodies, and a dramatic response to immunosuppression. Various environmental and genetic influences can trigger the immune mediated destruction of the liver. A plethora of clinical presentations can be seen ranging from chronic indolent disease to fulminant hepatic failure. Autoimmune hepatitis does not have a pathognomonic feature, and its laboratory, serologic, and histologic manifestations are found in acute and chronic liver disease of diverse causes. Difficulties in distinguishing toxic, drug-related, virus-induced, and autoimmune causes of severe acute liver injury can result in misclassification. Our paper discusses autoimmune hepatitis, giving a detailed overview of its clinical presentation, immunopathogenesis, emphasis on histomorphological changes and the diagnostic criteria.</span></p><p><span style="font-family: Calibri;">Journal of Pathology of Nepal (2012) Vol. 2, 317-323</span></p><p><span style="font-family: Calibri;">DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i4.6887">http://dx.doi.org/10.3126/jpn.v2i4.6887</a></span></p> ER -