TY - JOUR AU - Umar, Tungki Pratama AU - Wijaya, Fernando AU - Ernanto, Junoretta Haviva AU - Parulian, Theodorus PY - 2020/06/10 Y2 - 2024/03/29 TI - The Effect of Lansium domesticum Corr. (Duku) Seed Extract on Wound Healing JF - Journal of Nobel Medical College JA - J Nobel Med Coll VL - 9 IS - 1 SE - Original Articles DO - 10.3126/jonmc.v9i1.29395 UR - https://www.nepjol.info/index.php/JoNMC/article/view/29395 SP - 8-11 AB - <p><strong>Background: </strong>A wound is an injury caused by a cut, blow, or any else that typically involves laceration. For the treatment of infections and promoting wound healing, povidone-iodine is usually used but sometimes it can lead to irritation. The researcher would like to develop&nbsp;<em>Lansium </em><em>d</em><em>omesticum&nbsp;</em>Corr. (duku) seed extract ointment to promote wound healing.</p><p><strong>Materials and Methods:</strong> This experimental study was done on 30 rats which are divided into six groups namely negative control, positive control (povidone-iodine 10%), the experimental group with three different concentration of&nbsp;<em>Lansium </em><em>d</em><em>omesticum</em>&nbsp;seed extract ointment (2.5%, 5%, and 10%) and followed for three days to assess wound size. Approval was acquired by the Research Ethics Committee of the Sriwijaya University Faculty of Medicine, Palembang, Indonesia. In vitro capacity of&nbsp;<em>Lansium </em><em>d</em><em>omesticum</em>&nbsp;extract also assessed by measuring inhibitory diameter.</p><p><strong>Results:</strong> After three days of treatment, there is a significant difference in wound closure for all groups (p&lt;0.05) except for the negative control group. The best wound closure was found in a 10% extract group with average wound size decreasing by 0.3 cm. For in vitro activity, only 10%&nbsp;<em>Lansium</em><em> d</em><em>omesticum</em>&nbsp;seed extract ointment which is showing inhibitory zone at 3 mm of diameter.</p><p><strong>Conclusion:</strong> <em>Lansium Domesticum</em>&nbsp;Corr. seed extract ointment has the potency to promote wound healing on rats in addition to its small antimicrobial activity.</p> ER -