Fabrication Of Glimepiride <i>Datura Stramonium</i> Leaves Mucilage And Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets: <i>In Vitro</i> Evaluation

Authors

  • Abdul Ahad Hindustan Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh
  • U Anand Babu Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh
  • K Nagesh Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh
  • D Sai Kiran Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh
  • K Bindu Madhavi Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh

DOI:

https://doi.org/10.3126/kuset.v8i1.6044

Keywords:

Glimepiride, Datura stramonium, Poly Vinyl Pyrrolidone, matrix tablets, sustained release.

Abstract

The main purpose of the present work was to develop matrix tablets of Glimepiride with Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Datura stramonium leaves was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Datura stramonium leaves were studied. Various formulations of Glimepiride Datura stramonium leave mucilage and Poly Vinyl Pyrrolidone were prepared. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in vitro drug release pattern and the dissolution data was treated with mathematical modeling and the optimized formulation was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone combination can be used as a matrix forming material for making sustained release matrix tablets.

DOI: http://dx.doi.org/10.3126/kuset.v8i1.6044

KUSET 2012; 8(1): 63-72

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How to Cite

Hindustan, A. A., Babu, U. A., Nagesh, K., Kiran, D. S., & Madhavi, K. B. (2012). Fabrication Of Glimepiride <i>Datura Stramonium</i> Leaves Mucilage And Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets: <i>In Vitro</i> Evaluation. Kathmandu University Journal of Science, Engineering and Technology, 8(1), 63–72. https://doi.org/10.3126/kuset.v8i1.6044

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Original Research Articles