Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

Authors

  • Madhu Thapa Department of Ophthalmology, BP Koirala Lion’s Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu
  • Safal Khanal Department of Ophthalmology, BP Koirala Lion’s Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu
  • Gulsan B Shrestha Department of Ophthalmology, BP Koirala Lion’s Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu
  • Ananda K Sharma Department of Ophthalmology, BP Koirala Lion’s Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu

DOI:

https://doi.org/10.3126/nepjoph.v6i2.11709

Keywords:

retinal nerve fibre layer, optical coherence tomography, optic nerve head

Abstract

Objective: To determine the normal values for peripapillary retinal nerve fibre layer thickness (RNFL) measured by spectral domain optical coherence tomography (SD- OCT) in a healthy Nepalese population and to compare the RNFL thicknesses between the genders and among the various age groups.

Material and methods: One hundred and fifty six eyes of 156 healthy Nepalese subjects (66 males and 88 females) of various age groups were enrolled in this observational, cross-sectional, hospital-based study. The peripapillary RNFL of the randomly chosen eye of each subject was imaged with a high resolution SD-OCT (Spectralis HRA+OCT, Heidelberg Engineering). The RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive, circular B scans with a 3.4 mm diameter and compared between the genders and among the various age groups.

Results: The mean age of the subjects was 38.94 ± 17.00 years (range - 14 to 76 years). The average peripapillary RNFL was found to be 102.64 ± 9.56 μm (95 % CI 97.01 - 101.93). The mean ± SD peripapillary RNFL measurements at the superior, nasal, inferior and temporal sectors in the study population were 129.51 ± 15.09 μm, 76.55 ± 12.02 μm, 134.53 ± 17.19 μm and 70.74 ± 15.53 μm respectively. The average RNFL thickness was 99.47 ± 10.18 μm in the male whereas it was 105.09 ± 8.31 μm in the female participants. The RNFL decreased by 2.26 μm per age per decade.  

Conclusion: The Average RNFL thickness is 102.64 ± 9.56 μm in the Nepalese population. Gender and age related variation in the RNFL could serve as a useful guideline in the diagnosis of glaucoma in our population.

DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11709

Nepal J Ophthalmol 2014; 6(12): 131-139

 

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Author Biography

Madhu Thapa, Department of Ophthalmology, BP Koirala Lion’s Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu

MD, Assistant Professor

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Published

2014-12-13

How to Cite

Thapa, M., Khanal, S., Shrestha, G. B., & Sharma, A. K. (2014). Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography. Nepalese Journal of Ophthalmology, 6(2), 131–139. https://doi.org/10.3126/nepjoph.v6i2.11709

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Original Articles