Clinical spectrum of HLA-B27-associated ocular inflammation

Authors

  • Richa Pyare Retina and Uvea Services, Shroff Eye Centre, New Delhi, India
  • Parthopratim Dutta Majumder Uvea Services, Medical Research foundation, Sankara Nethralaya, Chennai, India https://orcid.org/0000-0002-5843-5192

DOI:

https://doi.org/10.3126/nepjoph.v14i2.50679

Keywords:

Ankylosing spondylitis, Anterior uveitis, HLA B27, Spondyloarthropathy, Uveitis

Abstract

Introduction: HLA-B27-associated anterior uveitis is the most common identifiable cause of anterior uveitis in adults worldwide. It is associated with significant ocular morbidity in young patients due to its typically recurrent attacks of inflammation and vision-threatening ocular complications.

Materials and methods: This review was compiled using articles identified by searching on PubMed with all relevant keywords such as HLA B27, HLA B27 uveitis, spondyloarthritis, Ankylosing spondylitis, HLA B27 systemic associations.

Results: We summarize the current knowledge on the HLA B27 associated uveitis epidemiology, genetics, clinical profile, systemic associations, laboratory investigations, complications and management.

Conclusion: HLA-B27-associated uveitis is a commonly encountered entity in the uveitic clinic. Its management must be in coordination with a rheumatologist. Early and appropriately intense treatment is essential for optimal visual prognosis.

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Published

2022-12-31

How to Cite

Pyare, R., & Majumder, P. D. (2022). Clinical spectrum of HLA-B27-associated ocular inflammation. Nepalese Journal of Ophthalmology, 14(2), 116–134. https://doi.org/10.3126/nepjoph.v14i2.50679

Issue

Section

Review Article