TY - JOUR AU - Rajbhandari, Rajib AU - Tamrakar, Rikesh AU - Limbu, Yuba Raj AU - Singh, Satish AU - KC, Sanjay Singh PY - 2019/11/14 Y2 - 2024/03/29 TI - High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease JF - Nepalese Heart Journal JA - Nepalese Heart J. VL - 16 IS - 2 SE - Original Articles DO - 10.3126/njh.v16i2.26319 UR - https://www.nepjol.info/index.php/NHJ/article/view/26319 SP - 59-62 AB - <p><strong>Background and Aims:</strong> Patients with Coronary artery disease who undergo percutaneous coronary intervention (PCI)&nbsp;are prescribed with maintenance aspirin dose that vary between 75 mg to 300 mg daily. The objective of this study is to&nbsp;evaluate the effects of high dose versus low dose aspirin doses prescribed on hospital discharge in PCI.</p><p><strong>Methods:</strong> All the patients who had undergone PCI at our hospital from 2017 February to October 2017 were enrolled in&nbsp;the study. They were divided into two groups receiving low dose (&lt;200mg) aspirin and high dose (&gt;200mg) aspirin. Patients&nbsp;were interviewed on phone after completion of one year for the possible complications and new ischemic events during the&nbsp;follow up period.</p><p><strong>Results:</strong> Among 150 patients selected 101 fulfilled the criteria and sixty patients (59.4%) were discharged on low-dose&nbsp;aspirin 75-150mg and 41 patients (40.6%) were discharged on high-dose aspirin of 300mg. The mean age in low aspirin&nbsp;group was 59.8±13.19 years and 49.4±10.7 years in high aspirin group. Although high aspirin dose patients did not complain&nbsp;of epigastric pain more often, upper GI bleeding was significantly higher in high aspirin group 7.5% vs 11.1% (p&lt;0.05).&nbsp;One patient in high aspirin group had hemorrhagic stroke while low aspirin group had none. One patient in high aspirin had&nbsp;sudden cardiac death at home. Clinically, there was no significant difference in new ischemic events during follow up period.</p><p><strong>Conclusion:</strong> In patients with coronary artery disease undergoing PCI, discharge on high-dose rather than low-dose aspirin&nbsp;may increase the rate of bleeding without providing additional ischemic benefit.</p> ER -