Cutaneous Manifestations of Thyroid Hormone Disorder

Authors

  • Karuna Singh Sijapati BP Koirala Institute of Health Sciences https://orcid.org/0000-0003-4797-4542
  • Arpana Rijal BP Koirala Institute of Health Sciences
  • Sudha Agrawal BP Koirala Institute of Health Sciences
  • Dhan Keshar Khadka BP Koirala Institute of Health Sciences
  • Robin Maskey BP Koirala Institute of Health Sciences

DOI:

https://doi.org/10.3126/njdvl.v17i1.23217

Keywords:

Cutaneous changes, Hypothyroidism, Hyperthyroidism

Abstract

Introduction: Thyroid hormone disorder (THD), a major health problem, is associated with a wide range of diseases. One of the organs, which  shows this wide range of clinical signs is the skin. Some dermatological findings may be the first symptoms of THD. Therefore, this study was planned to determine various cutaneous manifestations of THD that can be used as a diagnostic marker for THD. In Nepal due to lack of awareness, thyroid diseases may go unnoticed .So, cutaneous manifestations help in early diagnosis and treatment of THD.

Objectives: To identify cutaneous manifestations of THD and to evaluate dermatological manifestations specific for THD. 

Materials and methods: Seventy six patients with diagnosis of THD attending endocrine clinic of Internal Medicine Department in BPKIHS, Dharan were consecutively assessed for cutaneous changes by detailed history and clinical examination. As a control group, 26 age and  sex matched individuals without THD were included to assess frequency of cutaneous manifestation in normal individuals. 

Results: Fifty five (72.3%) cases and 4(15.4%) control had skin changes. This observation was statistically significant with OR-14.4(95% CI4.43 – 46.78) and p<0.001.Hair changes (OR-2.100, 95% CI 0.647-6.821 and p=0.210) and nail changes (OR-1.818, 95% CI 0.371-8.902 and p=0.726) had no statistically significant association with THD.

Conclusion: THD may present as or be associated with many changes in skin, hair and nails.

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Author Biographies

Karuna Singh Sijapati, BP Koirala Institute of Health Sciences

Senior Resident, Department of Dermatology

Arpana Rijal, BP Koirala Institute of Health Sciences

Professor, Department of Dermatology and Venereology

Sudha Agrawal, BP Koirala Institute of Health Sciences

Professor, Department of Dermatology and Venereology

Dhan Keshar Khadka, BP Koirala Institute of Health Sciences

Associate Professor, Department of Dermatology and Venereology

Robin Maskey, BP Koirala Institute of Health Sciences

Additional Professor, Department of Internal Medicine

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Published

2019-03-31

How to Cite

Sijapati, K. S., Rijal, A., Agrawal, S., Khadka, D. K., & Maskey, R. (2019). Cutaneous Manifestations of Thyroid Hormone Disorder. Nepal Journal of Dermatology, Venereology &Amp; Leprology, 17(1), 42–48. https://doi.org/10.3126/njdvl.v17i1.23217

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Section

Original Articles