Efficacy of Topical 5% 5-Fluorouracil and 0.05% Tretinoin and Electrosurgery in the Treatment of Plane Warts: A Randomized Controlled Comparative Trial

  • Rashmi Singh Department of Dermatology, Heritage Institute of Medical Sciences, Vanarashi, India
  • Shyam Sundar Pandey Department of Dermatology, Heritage Institute of Medical Science, Vanarashi, India
Keywords: efficacy, electrosurgery, Flurouracil, Plane warts, Tretinoin

Abstract

Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence. Plane wart is one of the morphological varients accounting for approximately one fifth of HPV lesions. Treatment of plane warts is difficult and recurrence quite common .The objective of our study is to compare the efficacy and safety of 5% 5 –fluorouracil (5 FU),0.5% tretinoin and electrosurgery in the treatment of plane wart. Seventy five patients 38 males and 37 females were included in this randomized controlled comparative  trial .Patients were age and sex matched and divided into three groups, GROUP A : Patients treated with 5% 5-Fluorouracil ,GROUP B:Patients treated with 0.5% tretinoin and GROUP C : Patients treated with electrodessication .While topical treatments were applied once nightly for 4 weeks(5% 5-fluorouracil for four hours and tretinoin overnight), radiodessication was done at first visit only.Result and conclusion:While radiofrequency showed faster results , results were more consistent with least recurrence in 5-FU and fair recurrence with .05% tretinoin.

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Author Biographies

Rashmi Singh, Department of Dermatology, Heritage Institute of Medical Sciences, Vanarashi, India

Assistant Professor, Department of Dermatology, Heritage Institute of Medical Sciences, Vanarashi, India

Shyam Sundar Pandey, Department of Dermatology, Heritage Institute of Medical Science, Vanarashi, India
Prof and Head, Department of Dermatology, IMS,BHU Ex Prof and Head, Department of Dermatology, Heritage Institute of Medical Sciences, Vanarashi, India  
Published
2021-04-02
How to Cite
Singh, R., & Pandey, S. (2021). Efficacy of Topical 5% 5-Fluorouracil and 0.05% Tretinoin and Electrosurgery in the Treatment of Plane Warts: A Randomized Controlled Comparative Trial. Nepal Journal of Dermatology, Venereology & Leprology, 19(1), 55-59. https://doi.org/10.3126/njdvl.v19i1.28322
Section
Original Articles