Cutaneous Manifestations in Renal Transplant Recipients

  • Anil Kumar Das Department of Dermatology and Venereology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
  • Ramesh Sharma Department of Dermatology, Green Pastures Hospital, Pokhara, Nepal
  • Ashish Karn Medical Officer, Nepal Medicity Hospital, Lalitpur, Nepal
Keywords: Renal transplant recipients, cutaneous manifestations

Abstract

Background:

The availability of potent immunosuppressants has paved the path towards decreased incidence of graft rejection and long term survival of the renal transplant recipients. But, with the increased life span of the patients and long term use of immunosuppressants, there has been an increase in various skin conditions; ranging from various infections to some life-threatening cutaneous malignancies.

Objectives:

This study was carried out to determine the pattern of different cutaneous manifestations in renal transplant recipients at Tribhuvan University Teaching Hospital, to identify the infectious and non-infectious skin manifestations in these patients and their relation with the duration of transplantation.

Methodology:

The present study was a hospital based cross-sectional descriptive study conducted at Tribhuvan University Teaching Hospital, Kathmandu; Department of Internal Medicine, Transplant Outpatient department and Outpatient department of Department of Dermatology from June 2013 to May 2014. A total of 114 renal transplant recipients were enrolled in the study.

Results:

A total of 114 renal transplant recipients with a mean age of 37.56±11.10 years were studied. The immunosuppressive regimen consisted of combinations including tacrolimus, prednisolone,   mycophenolate mofetil/azathioprine along with supportive medications like antivirals, antibiotics and antihypertensives. Out of all those studied, 60 patients had a total of 61 cutaneous manifestations. The mean duration from date of transplantation to presentation to the transplant OPD for infectious dermatoses was 688.4 days (1.88 years) and for iatrogenic dermatoses was 67.5 days. The most common cutaneous manifestation was acne (41%) followed by fungal infections (27.9%) consisting of pityriasis versicolor (n=9), dermatophytosis (n=6) and candidiasis (n=2); viral infections (18%) consisting of verruca (n=4), herpes zoster (n=4) and herpes simplex (n=3); bacterial infections (4.9%) consisting of folliculitis (n=2) and erythema chronicum migrans (n=1). Gingival hyperplasia was observed in a single patient. Other cutaneous manifestations like seborrheic dermatitis and xerosis were also observed in 2 patients each during the study.

 

Conclusion:

Renal transplant recipients are susceptible to acquire various cutaneous manifestations as a result of long term immunosuppression and also due to adverse effects of the drugs used. This knowledge helps the transplant physicians for regular dermatologic screening of these patients for early diagnosis and treatment of the skin lesions.

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Author Biographies

Anil Kumar Das, Department of Dermatology and Venereology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Associate Professor

Department of Dermatology and Venereology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Ramesh Sharma, Department of Dermatology, Green Pastures Hospital, Pokhara, Nepal

Consultant Dermatologist, Department of Dermatology, Green Pastures Hospital, Nayagaun, Pokhara.

Ashish Karn, Medical Officer, Nepal Medicity Hospital, Lalitpur, Nepal

Medical Officer, Nepal Mediciti Hospital, Lalitpur, Nepal

Published
2021-04-02
How to Cite
Das, A., Sharma, R., & Karn, A. (2021). Cutaneous Manifestations in Renal Transplant Recipients. Nepal Journal of Dermatology, Venereology & Leprology, 19(1), 42-49. https://doi.org/10.3126/njdvl.v19i1.35953
Section
Original Articles