Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

  • Aruna Sayami Department of Dermatology, Venerology and Leprology, Institute of Medicine, Tribhuwan University
  • Aatmaram Gupta Department of Dermatology, Venerology and Leprology Universal College of Medical Sciences, Bhairahawa, Nepal
  • Narayan Gautam Department of Microbiology, Universal College of Medical Sciences, Bhairahawa
Keywords: hyperuricemia, psoriasis, psoriatic arthritis, serum uric acid.

Abstract

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis.

Objectives: To find out the association of serum uric acid with psoriasis.

Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied.

Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis.

Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

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Author Biographies

Aruna Sayami, Department of Dermatology, Venerology and Leprology, Institute of Medicine, Tribhuwan University

Department of Dermatology and Venerology, Institute of  Medicine, Tribhuwan University, Kathmandu, Nepal

Aatmaram Gupta, Department of Dermatology, Venerology and Leprology Universal College of Medical Sciences, Bhairahawa, Nepal

Associate Professor, Department of Dermatology, Venerology and Leprology, Universal College of Medical Sciences, Bhairahawa

Narayan Gautam, Department of Microbiology, Universal College of Medical Sciences, Bhairahawa

Associate Professor, Department of Microbiology, Universal College of Medical Sciences, Bhairahawa, Nepal

 

Published
2021-04-02
How to Cite
Sayami, A., Gupta, A., & Gautam, N. (2021). Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study. Nepal Journal of Dermatology, Venereology & Leprology, 19(1), 50-54. https://doi.org/10.3126/njdvl.v19i1.35958
Section
Original Articles