Clinico-Histopathological Study of Cicatricial Alopecia in a Tertiary Care Center

Authors

  • Muna Bista Bhaktapur Cancer Hospital, Bhaktapur https://orcid.org/0000-0002-6019-0964
  • Dhan Keshar Khadka BP Koirala Institute of Health Sciences, Dharan
  • Paricha Upadhyaya BP Koirala Institute of Health Sciences. Dharan

DOI:

https://doi.org/10.3126/njdvl.v20i1.38206

Keywords:

Alopecia, Cicatrix, Pathology

Abstract

Introduction: Cicatricial alopecia (CA) comprises a group of disorders characterized by permanent destruction of the hair follicle and fibrosis on histopathologic examination. The similarities in the clinical presentation of various types of this disorder cause difficulty in prompt diagnosis, so histopathological assessment plays a pivotal role in the diagnosis.

Objectives: This study aimed to assess the clinical variants of cicatricial alopecia and compare the histopathology of the various subtypes.

Materials and Methods: In this cross-sectional study, 22 patients of cicatricial alopecia were enrolled and punch biopsies from the active site were taken for histopathological examination. Statistical analysis and correlation of clinical and histopathological features were done.

Results: Out of the 22 patients, 10 cases (45.45%) were confirmed as Lichen Planopilaris (LPP), seven (31.81%) as Discoid Lupus Erythematosus (DLE), two (9%) as Morphea, one (4.5%) each as Pseudopelade, Central Centrifugal Cicatricial Alopecia (CCCA) and Dissecting cellulitis (DC). There was a fair agreement between clinical and histopathological diagnoses (Kappa=0.384). The age ranged from 10 years to 60 years with the mean age of 32.32 ± 15.51 years.

Conclusion: There is high clinical and histopathological variability and similarities among the variants of CA, which represents a true diagnostic challenge. A precise and early diagnosis is possible if the clinico-histopathological correlation is employed.

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Author Biographies

Muna Bista, Bhaktapur Cancer Hospital, Bhaktapur

 

Consultant Dermatologist and Venereologist, Bhaktapur Cancer Hospital, Bhaktapur

Dhan Keshar Khadka, BP Koirala Institute of Health Sciences, Dharan

Associate Professor, Department of Dermatology, Venereology and Leprology

BP Koirala Institute of Health Sciences, Dharan

Paricha Upadhyaya, BP Koirala Institute of Health Sciences. Dharan

Professor, Department of Pathology, BP Koirala Institute of Health Sciences, Dharan

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Published

2022-03-29

How to Cite

Bista, M., Khadka, D. K., & Upadhyaya, P. (2022). Clinico-Histopathological Study of Cicatricial Alopecia in a Tertiary Care Center. Nepal Journal of Dermatology, Venereology &Amp; Leprology, 20(1), 12–18. https://doi.org/10.3126/njdvl.v20i1.38206

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Original Articles