Single Dose Pharmacokinetics of Lamivudine in Healthy Volunteers: Comparison of Blood and Urine Kinetics

Authors

  • G Ramachandran Department of Clinical Research, Tuberculosis Research Centre, Chennai, India
  • AK Hemanth Kumar Department of Clinical Research, Tuberculosis Research Centre, Chennai, India
  • V Venkatesan Department of Clinical Pharmacology, Madras Medical College, Chennai, India
  • S Anitha Department of Clinical Research, Tuberculosis Research Centre, Chennai, India
  • CB Tharani Department of Clinical Pharmacology, Madras Medical College, Chennai, India
  • V Kumaraswami Department of Clinical Research, Tuberculosis Research Centre, Chennai, India
  • S Swaminathan Department of Clinical Research, Tuberculosis Research Centre, Chennai, India

DOI:

https://doi.org/10.3126/saarctb.v5i2.3069

Keywords:

lamivudine, plasma, urine, compliance to treatment

Abstract

Aims: To study single dose pharmacokinetics of lamivudine (3TC) in healthy subjects.

Methods: Twelve healthy subjects were administered 3TC (150 mg) followed by timed blood and urine collections up to 24 hours. Pharmacokinetic variables and percent dose of 3TC in urine were calculated.

Results: Plasma exposure and percent dose of 3TC in urine were highly correlated (p < 0.001; r = 0.96). 3TC concentration at 24 hours was undetectable in all study subjects.

Conclusions: Timed urine measurements could be used to study bioavailabilty of 3TC. Plasma 3TC measurements could be used to monitor adherence among HIV-infected patients on antiretroviral treatment.

Key words: lamivudine; plasma; urine; compliance to treatment  

DOI: 10.3126/saarctb.v5i2.3069

SAARC J. Tuber. Lung Dis. HIV/AIDS 2008 Vol.5(2) 6-9

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Published

2010-05-07

How to Cite

Ramachandran, G., Kumar, A. H., Venkatesan, V., Anitha, S., Tharani, C., Kumaraswami, V., & Swaminathan, S. (2010). Single Dose Pharmacokinetics of Lamivudine in Healthy Volunteers: Comparison of Blood and Urine Kinetics. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS, 5(2), 6–9. https://doi.org/10.3126/saarctb.v5i2.3069

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