@article{Siribaddana_Dissanayake_Athukorala_Pathirathne_Senevirathna_Upul_Wickramasekara_Nishantha_Kumarasinghe_Dassanayake_2016, title={Frequency of Adverse Effects of Fixed Dose Combinations, in Tuberculosis and there Effects on Treatment Outcome}, volume={12}, url={https://www.nepjol.info/index.php/SAARCTB/article/view/15949}, DOI={10.3126/saarctb.v12i2.15949}, abstractNote={<p><strong>Introduction: </strong>This study was designed to assess the frequency, types and impact of adverse drug reactions (ADR) to category 1 anti-tubercular therapy using fixed drug combinations (FDC). Patients with tuberculosis started on anti TB treatment from 01st of July 2011 to 30th of June 2012 were recruited</p><p><strong>Methodology: </strong>Patients were followed up for development of ADR. Frequency of ADR, number of patients who required prolongation of therapy, who had alternate regimes, and there treatment outcome were recorded.</p><p><strong>Results: </strong>Out of 280 patients with tuberculosis 67 (24%), 37 (55.2%) males, 30 (44.8%) females ADR. Thirty three out of 74 (44%) of total population above the age of 60 had ADR, while only 34 out of 206 (16.5%) of patients below the age of 60 had ADR (Chi= 23, p <0.0001). Incidence of ADR were - Dyspeptic symptoms 31(11.1%), itching 20 (7.1%), hepatitis 9 (3.2%), arthralgia 1 (0.4%), vertigo 1 (0.4%), peripheral neuropathy 1 (0.4%), visual impairment 1 (0.4%), rash 1 (0.4%). Out of 27 patients who had prolongation of therapy 22 (81.4%) were due to ADR (Chi = 54, p <0.0001). Nine (3.2%) were given alternate regimes (Fishers exact p = 0.000017) [6 hepatitis, 1 rash, 1 vertigo, 1 visual impairment]. None of the patients with ADR had relapses or treatment failures.</p><p><strong>Conclusion: </strong>Adverse reactions were commoner among the elderly, and were associated with prolongation and modification of anti tuberculosis therapy but over all treatment outcomes were not adversely affected.</p><p><strong>SAARC J TUBER LUNG DIS HIV/AIDS,</strong> 2015 XII (2),Page: 8-12</p>}, number={2}, journal={SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS}, author={Siribaddana, A and Dissanayake, KS and Athukorala, GP and Pathirathne, H and Senevirathna, KP and Upul, BKM Asanga and Wickramasekara, K and Nishantha, PLB and Kumarasinghe, E and Dassanayake, DLB}, year={2016}, month={Oct.}, pages={8–12} }